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Results: 30762
Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality
BACKGROUND: Randomised trials of vitamin D supplementation for cardiovascular disease and all-cause mortality have generally reported null findings. However, generalisability of results to individuals with low vitamin D status...
Assessing risk prediction models using individual participant data from multiple studies.
Lisa Pennells, Stephen Kaptoge, Ian R White, Simon G Thompson, Angela M Wood, Emerging Risk Factors Collaboration
Sep 06, 2019
Individual participant time-to-event data from multiple prospective epidemiologic studies enable detailed investigation into the predictive ability of risk models. Here we address the challenges in appropriately combining such...
C index D measure coronary heart disease individual participant data inverse variance Meta-Analysis Risk prediction weighting C-Reactive Protein Coronary Disease Data Interpretation Statistical Female Humans Male Meta-Analysis as Topic Middle Aged Models Statistical Proportional Hazards Models Prospective Studies Risk Assessment Risk Factors
Meta-analysis of non-linear exposure-outcome relationships using individual participant data
Ian R White, Stephen Kaptoge, Patrick Royston, Willi Sauerbrei, Emerging Risk Factors Collaboration
Nov 30, 2018
Non-linear exposure-outcome relationships such as between body mass index (BMI) and mortality are common. They are best explored as continuous functions using individual participant data from multiple studies. We explore two...
SCORE2-OP risk prediction algorithms
AIMS: The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model to estimate 5- and 10-year risk of cardiovascular disease (CVD) in individuals aged over 70 years in four geographical risk...
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations.
Fränzel JB van Duijnhoven, Mazda Jenab, Kristian Hveem, Peter D Siersema, Veronika Fedirko, Eric J Duell, Ellen Kampman, Anouk Halfweeg, Henk J van Kranen, Jody MW van den Ouweland, Elisabete Weiderpass, Neil Murphy, Arnulf Langhammer, Eivind Ness-Jensen, Anja Olsen, Anne Tjønneland, Kim Overvad, Claire Cadeau, Marina Kvaskoff, Marie-Christine Boutron-Ruault, Verena A Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Anastasia Kotanidou, Maria Kritikou, Domenico Palli, Claudia Agnoli, Rosario Tumino, Salvatore Panico, Giuseppe Matullo, Petra Peeters, Magritt Brustad, Karina Standahl Olsen, Cristina Lasheras, Mireia Obón-Santacana, María-José Sánchez, Miren Dorronsoro, Maria-Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Martin Almquist, Frida Renström, Weimin Ye, Nick Wareham, Kay-Tee Khaw, Kathryn E Bradbury, Heinz Freisling, Dagfinn Aune, Teresa Norat, Elio Riboli, HB As Bueno-de-Mesquita
Jun 18, 2018
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to...
Monthly vitamin D supplementation, pain, and pattern of analgesic prescription
Zhenqiang Wu, Carlos A Camargo, Zarintaj Malihi, Jim Bartley, Debbie Waayer, Carlene MM Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
Aug 14, 2018
Observational studies suggest that vitamin D deficiency is associated with higher risk of pain. However, evidence on the effect of vitamin D supplementation on pain is limited and contradictory. The aim of this study was to...
Vitamin D and risk of cause specific death
Rajiv Chowdhury, Setor Kunutsor, Anna Vitezova, Clare Oliver-Williams, Susmita Chowdhury, Jessica C Kiefte-de-Jong, Hassan Khan, Cristina P Baena, Dorairaj Prabhakaran, Moshe B Hoshen, Becca S Feldman, An Pan, Laura Johnson, Francesca Crowe, Frank B Hu, Oscar H Franco
Nov 30, 2018
OBJECTIVE: To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances. DESIGN: Systematic review...
Vitamin D and COVID-19-Revisited.
Sreedhar Subramanian, George Griffin, Martin Hewison, Julian Hopkin, Rose Anne Kenny, Eamon Laird, Richard Quinton, David Thickett, Jonathan M Rhodes
Aug 07, 2022
Vitamin D, when activated to 1,25-dihydroxyvitamin D, is a steroid hormone that induces responses in several hundred genes, including many involved in immune responses to infection. Without supplementation, people living in...
Global prevalence and disease burden of vitamin D deficiency
Daniel E Roth, Steven A Abrams, John Aloia, Gilles Bergeron, Megan W Bourassa, Kenneth H Brown, Mona S Calvo, Kevin D Cashman, Gerald Combs, Luz María De-Regil, Maria Elena Jefferds, Kerry S Jones, Hallie Kapner, Adrian R Martineau, Lynnette M Neufeld, Rosemary L Schleicher, Tom D Thacher, Susan J Whiting
Jul 24, 2019
Vitamin D is an essential nutrient for bone health and may influence the risks of respiratory illness, adverse pregnancy outcomes, and chronic diseases of adulthood. Because many countries have a relatively low supply of foods...
Circulating vitamin D concentrations and risk of breast and prostate cancer
Xia Jiang, Niki L Dimou, Kawthar Al-Dabhani, Sarah J Lewis, Richard M Martin, Philip C Haycock, Marc J Gunter, Timothy J Key, Rosalind A Eeles, Kenneth Muir, David Neal, Graham G Giles, Edward L Giovannucci, Meir Stampfer, Brandon L Pierce, Joellen M Schildkraut, Shaneda Warren Andersen, Deborah Thompson, Wei Zheng, Peter Kraft, Konstantinos K Tsilidis, CRUK, BPC3, CAPS and PEGASUS consortia PRACTICAL
Apr 26, 2018
BACKGROUND: Observational studies have suggested an association between circulating vitamin D concentrations [25(OH)D] and risk of breast and prostate cancer, which was not supported by a recent Mendelian randomization (MR)...
Mendelian randomization Breast malignancy Prostate serum vitamin D concentrations Aged Breast Neoplasms Causality Female Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Polymorphism Single Nucleotide Prostatic Neoplasms Receptors Estrogen Risk Factors vitamin D
Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway.
Sergi Trias-Llimós, Lisa Pennells, Aage Tverdal, Alexander V Kudryavtsev, Sofia Malyutina, Laila A Hopstock, Olena Iakunchykova, Yuri Nikitin, Per Magnus, Stephen Kaptoge, Emanuele Di Angelantonio, David A Leon
Mar 15, 2021
Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an approach to doing...
Quantifying the contribution of established risk factors to cardiovascular mortality differences between Russia and Norway
Sergi Trias-Llimós, Lisa Pennells, Aage Tverdal, Alexander V. Kudryavtsev, Sofia Malyutina, Laila A. Hopstock, Olena Iakunchykova, Yuri Nikitin, Per Magnus, Stephen Kaptoge, Emanuele Di Angelantonio, David A. Leon
Nov 27, 2020
Abstract: Surprisingly few attempts have been made to quantify the simultaneous contribution of well-established risk factors to CVD mortality differences between countries. We aimed to develop and critically appraise an...
E-Collaboration and Academic Performance of Lecturers
Bilal Al-khateeb
Jan 01, 2024
Electronic collaboration is increasingly becoming more popular among both the practitioners and the academics; however, the practitioners have taken more advantage of it than the academics. Despite the importance of...
Published by: IGI Global Scientific Publishing
Pregnancy Vitamin D Supplementation and Childhood Bone Mass at Age 4 Years
Elizabeth M Curtis, Rebecca J Moon, Stefania D'Angelo, Sarah R Crozier, Nicholas J Bishop, Jaya Sujatha Gopal-Kothandapani, Stephen H Kennedy, Aris T Papageorghiou, Robert Fraser, Saurabh V Gandhi, Inez Schoenmakers, Ann Prentice, Hazel M Inskip, Keith M Godfrey, M Kassim Javaid, Richard Eastell, Cyrus Cooper, Nicholas C Harvey, MAVIDOS Trial Group
Aug 21, 2022
In the Maternal Vitamin D Osteoporosis Study (MAVIDOS) randomized trial, vitamin D supplementation in pregnancy did not lead to greater neonatal bone mass across the trial as a whole, but, in a prespecified secondary analysis by...
Low Frequency Synonymous Coding Variation in CYP2R1 has Large Effects on Vitamin D Level and Risk of Multiple Sclerosis
SJ Sawcer
Nov 28, 2017
Vitamin D insufficiency is common, correctable and influenced by genetic factors, and it has been associated with risk of several diseases. We sought to identify low-frequency genetic variants that strongly increased the risk of...
Risk factors for herpes simplex virus type-1 infection and reactivation
Harriet Forbes, Ben Warne, Lars Doelken, Nicole Brenner, Tim Waterboer, Robert Luben, Nicholas J Wareham, Charlotte Warren-Gash, Effrossyni Gkrania-Klotsas
May 15, 2019
BACKGROUND: The prevalence of, and risk factors for, herpes simplex virus type-1 (HSV-1) infection and reactivation in older individuals are poorly understood. METHODS: This is a prospective population-based study among...
Association of Cardiometabolic Multimorbidity With Mortality.
Emerging Risk Factors Collaboration, Emanuele Di Angelantonio, Stephen Kaptoge, David Wormser, Peter Willeit, Adam S Butterworth, Narinder Bansal, Linda M O'Keeffe, Pei Gao, Angela M Wood, Stephen Burgess, Daniel F Freitag, Lisa Pennells, Sanne A Peters, Carole L Hart, Lise Lund Håheim, Richard F Gillum, Børge G Nordestgaard, Bruce M Psaty, Bu B Yeap, Matthew W Knuiman, Paul J Nietert, Jussi Kauhanen, Jukka T Salonen, Lewis H Kuller, Leon A Simons, Yvonne T van der Schouw, Elizabeth Barrett-Connor, Randi Selmer, Carlos J Crespo, Beatriz Rodriguez, WM Monique Verschuren, Veikko Salomaa, Kurt Svärdsudd, Pim van der Harst, Cecilia Björkelund, Lars Wilhelmsen, Robert B Wallace, Hermann Brenner, Philippe Amouyel, Elizabeth LM Barr, Hiroyasu Iso, Altan Onat, Maurizio Trevisan, Ralph B D'Agostino, Cyrus Cooper, Maryam Kavousi, Lennart Welin, Ronan Roussel, Frank B Hu, Shinichi Sato, Karina W Davidson, Barbara V Howard, Maarten JG Leening, Maarten Leening, Annika Rosengren, Marcus Dörr, Dorly JH Deeg, Stefan Kiechl, Coen DA Stehouwer, Aulikki Nissinen, Simona Giampaoli, Chiara Donfrancesco, Daan Kromhout, Jackie F Price, Annette Peters, Tom W Meade, Edoardo Casiglia, Debbie A Lawlor, John Gallacher, Dorothea Nagel, Oscar H Franco, Gerd Assmann, Gilles R Dagenais, J Wouter Jukema, Johan Sundström, Mark Woodward, Eric J Brunner, Kay-Tee Khaw, Nicholas J Wareham, Eric A Whitsel, Inger Njølstad, Bo Hedblad, Sylvia Wassertheil-Smoller, Gunnar Engström, Wayne D Rosamond, Elizabeth Selvin, Naveed Sattar, Simon G Thompson, John Danesh
Mar 08, 2019
IMPORTANCE: The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE: To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS: Age- and...
Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function
John D Sluyter, Carlos A Camargo, Debbie Waayer, Carlene MM Lawes, Les Toop, Kay-Tee Khaw, Robert Scragg
May 23, 2018
Although observational studies suggest positive vitamin D-lung function associations, randomized trials are inconsistent. We examined effects of vitamin D supplementation on lung function. We recruited 442 adults (50-84 years...
forced expiratory volume in 1 s lung function Randomized controlled trial Spirometry vitamin D Aged Aged 80 and over Asthma Dietary Supplements Dose-Response Relationship Drug Double-Blind Method Female Follow-Up Studies Forced Expiratory Volume Humans Lung Male Middle Aged Pulmonary Disease Chronic Obstructive Spirometry vitamin D Vitamin D Deficiency
No Association Between Vitamin D Status and Risk of Barrett's Esophagus or Esophageal Adenocarcinoma
Jing Dong, Puya Gharahkhani, Wong-Ho Chow, Marilie D Gammon, Geoffrey Liu, Carlos Caldas, Anna H Wu, Weimin Ye, Lynn Onstad, Lesley A Anderson, Leslie Bernstein, Paul D Pharoah, Harvey A Risch, Douglas A Corley, Rebecca C Fitzgerald, Stomach and Esophageal Cancer Study Consortium, Prasad G Iyer, Brian J Reid, Jesper Lagergren, Nicholas J Shaheen, Thomas L Vaughan, Stuart MacGregor, Sharon Love, Claire Palles, Ian Tomlinson, Ines Gockel, Andrea May, Christian Gerges, Mario Anders, Anne C Böhmer, Jessica Becker, Nicole Kreuser, Rene Thieme, Tania Noder, Marino Venerito, Lothar Veits, Thomas Schmidt, Claudia Schmidt, Jakob R Izbicki, Arnulf H Hölscher, Hauke Lang, Dietmar Lorenz, Brigitte Schumacher, Rupert Mayershofer, Yogesh Vashist, Katja Ott, Michael Vieth, Josef Weismüller, Markus M Nöthen, Susanne Moebus, Michael Knapp, Wilbert HM Peters, Horst Neuhaus, Thomas Rösch, Christian Ell, Janusz Jankowski, Johannes Schumacher, Rachel E Neale, David C Whiteman, Aaron P Thrift
Nov 01, 2019
BACKGROUND & AIMS: Epidemiology studies of circulating concentrations of 25 hydroxy vitamin D (25(OH)D) and risk of esophageal adenocarcinoma (EAC) have produced conflicting results. We conducted a Mendelian randomization study...
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors
Emma A Hurst, Richard J Mellanby, Ian Handel, David M Griffith, Adriano G Rossi, Timothy S Walsh, Manu Shankar-Hari, Jake Dunning, Natalie Z Homer, Scott G Denham, Kerri Devine, Paul A Holloway, Shona C Moore, Ryan S Thwaites, Romit J Samanta, Charlotte Summers, Hayley E Hardwick, Wilna Oosthuyzen, Lance Turtle, Malcolm G Semple, Peter JM Openshaw, J Kenneth Baillie, Clark D Russell, ISARIC4C investigators
Oct 04, 2021
OBJECTIVES: The steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in...
The double-edged sword of industry collaboration
This paper studies the impact of university-industry collaboration on academic research output. We analyze the channels through which the degree of industry collaboration may be affecting research output. We exploit a unique...
The double-edged sword of industry collaboration
This paper studies the impact of university-industry collaboration on academic research output. We analyze the channels through which the degree of industry collaboration may be affecting research output. We exploit a unique...
Vitamin D3 Supplementation Reduces the Symptoms of Upper Respiratory Tract Infection during Winter Training in Vitamin D-Insufficient Taekwondo Athletes
Vitamin D insufficiency may be associated with increased risk of upper respiratory tract infection (URTI) in athletes. This study examined the effects of vitamin D3 supplementation on salivary immune functions and symptoms of...
high-intensity training respiratory immune function secretory immunoglobulin vitamin D Exercise Science Kinesiology
Published by: Digital Commons @ Texas A&M University-San Antonio
A Novel Method for Measuring, Visualizing, and Monitoring E-Collaboration
With its roots in the 1960s, e-collaboration has dramatically evolved and expanded over the past decades and became a globally adopted practice of teamwork. On the other hand, despite the development of e-collaboration...
Published by: IGI Global Scientific Publishing
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