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EU-AIMS Longitudinal European Autism Project (LEAP)
Johan Isaksson, Kristiina Tammimies, Janina Neufeld, Élodie Cauvet, Karl Lundin, Jan K Buitelaar, Eva Loth, Declan GM Murphy, Will Spooren, Sven Bölte, EU-AIMS LEAP group
May 09, 2019
EU-AIMS is the largest European research program aiming to identify stratification biomarkers and novel interventions for autism spectrum disorder (ASD). Within the program, the Longitudinal European Autism Project (LEAP) has...
Investigating the factors underlying adaptive functioning in autism in the EU-AIMS Longitudinal European Autism Project.
Julian Tillmann, Antonia San José Cáceres, Chris H Chatham, Daisy Crawley, Rosemary Holt, Bethany Oakley, Tobias Banaschewski, Simon Baron-Cohen, Sven Bölte, Jan K Buitelaar, Sarah Durston, Lindsay Ham, Eva Loth, Emily Simonoff, Will Spooren, Declan G Murphy, Tony Charman, EU-AIMS LEAP group
May 03, 2019
Individuals with autism spectrum disorder (ASD) exhibit significant impairments in adaptive functioning that impact on their ability to meet the demands of everyday life. A recurrent finding is that there is a pronounced...
adaptive functioning Autism spectrum disorder intellectual functioning psychiatric symptoms symptom severity Activities of Daily Living Adolescent Adult Age Factors Autism spectrum disorder Child Cohort Studies Europe Female Humans Intelligence Longitudinal Studies Male Phenotype Severity of Illness Index Sex Factors Young Adult
The EU-AIMS Longitudinal European Autism Project (LEAP)
Eva Loth, Tony Charman, Luke Mason, Julian Tillmann, Emily JH Jones, Caroline Wooldridge, Jumana Ahmad, Bonnie Auyeung, Claudia Brogna, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Michael Brammer, Daniel Brandeis, Sven Bölte, Thomas Bourgeron, Carsten Bours, Yvette de Bruijn, Bhismadev Chakrabarti, Daisy Crawley, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Hannah Hayward, Lindsay M Ham, Joerg Hipp, Rosemary J Holt, Mark H Johnson, Johan Isaksson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Amber NV Ruigrok, Barbara Ruggeri, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve CR Williams, Marcel P Zwiers, Will Spooren, Declan GM Murphy, Jan K Buitelaar
Jun 23, 2017
BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular...
Biomarkers Cognition EEG eye-tracking Genetics MRI Neuroimaging Adult Autism spectrum disorder Biomarkers Brain Child Eye Movement Measurements Female Genetic Heterogeneity Hair Humans Individuality Longitudinal Studies Magnetic Resonance Imaging Male Neuroimaging Patient Selection Phenotype Precision Medicine Saliva Siblings
Gray matter covariations and core symptoms of autism
Ting Mei, Alberto Llera, Dorothea L Floris, Natalie J Forde, Julian Tillmann, Sarah Durston, Carolin Moessnang, Tobias Banaschewski, Rosemary J Holt, Simon Baron-Cohen, Annika Rausch, Eva Loth, Flavio Dell'Acqua, Tony Charman, Declan GM Murphy, Christine Ecker, Christian F Beckmann, Jan K Buitelaar, EU-AIMS LEAP group
Dec 07, 2020
BACKGROUND: Voxel-based morphometry (VBM) studies in autism spectrum disorder (autism) have yielded diverging results. This might partly be attributed to structural alterations being associating with the combined influence of...
The EU-AIMS Longitudinal European Autism Project (LEAP)
Tony Charman, Eva Loth, Julian Tillmann, Daisy Crawley, Caroline Wooldridge, David Goyard, Jumana Ahmad, Bonnie Auyeung, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary J Holt, Johan Isaksson, Mark H Johnson, Emily JH Jones, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Luke Mason, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Barbara Ruggeri, Amber NV Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San Jóse Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve CR Williams, Marcel P Zwiers, Will Spooren, Declan GM Murphy, Jan K Buitelaar
Jun 23, 2017
BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the...
Age autism Autism spectrum disorder Behaviours Heterogeneity IQ Phenotype sex Adolescent Adult Age Factors Autism spectrum disorder Biomarkers Child Female Genetic Heterogeneity Humans Impulsive Behavior Individuality Longitudinal Studies Male Parents Phenotype Self Report Severity of Illness Index Sex Factors Surveys and Questionnaires
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry.
Natasha Bertelsen, Isotta Landi, Richard AI Bethlehem, Jakob Seidlitz, Elena Maria Busuoli, Veronica Mandelli, Eleonora Satta, Stavros Trakoshis, Bonnie Auyeung, Prantik Kundu, Eva Loth, Guillaume Dumas, Sarah Baumeister, Christian F Beckmann, Sven Bölte, Thomas Bourgeron, Tony Charman, Sarah Durston, Christine Ecker, Rosemary J Holt, Mark H Johnson, Emily JH Jones, Luke Mason, Andreas Meyer-Lindenberg, Carolin Moessnang, Marianne Oldehinkel, Antonio M Persico, Julian Tillmann, Steve CR Williams, Will Spooren, Declan GM Murphy, Jan K Buitelaar, EU-AIMS LEAP group, Simon Baron-Cohen, Meng-Chuan Lai, Michael V Lombardo
May 26, 2021
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural...
Fractionating autism based on neuroanatomical normative modeling.
Mariam Zabihi, Dorothea L Floris, Seyed Mostafa Kia, Thomas Wolfers, Julian Tillmann, Alberto Llera Arenas, Carolin Moessnang, Tobias Banaschewski, Rosemary Holt, Simon Baron-Cohen, Eva Loth, Tony Charman, Thomas Bourgeron, Declan Murphy, Christine Ecker, Jan K Buitelaar, Christian F Beckmann, Andre Marquand, EU-AIMS LEAP group
Dec 07, 2020
Autism is a complex neurodevelopmental condition with substantial phenotypic, biological, and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism into replicable cognitive or biological...
Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder.
Nico Bast, Luke Mason, Christine M Freitag, Tim Smith, Ana Maria Portugal, Luise Poustka, Tobias Banaschewski, Mark Johnson, EU-AIMS LEAP group
Apr 12, 2021
BACKGROUND: Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual exploration is understudied, whereas oculomotor function during...
Evaluation of data imputation strategies in complex, deeply-phenotyped data sets
A Llera, M Brammer, B Oakley, J Tillmann, M Zabihi, JS Amelink, T Mei, T Charman, C Ecker, F Dell'Acqua, T Banaschewski, C Moessnang, S Baron-Cohen, R Holt, S Durston, D Murphy, E Loth, JK Buitelaar, DL Floris, CF Beckmann
Sep 15, 2022
An increasing number of large-scale multi-modal research initiatives has been conducted in the typically developing population, e.g. Dev. Cogn. Neur. 32:43-54, 2018; PLoS Med. 12(3):e1001779, 2015; Elam and Van Essen, Enc. Comp....
Evaluation of data imputation strategies in complex, deeply-phenotyped data sets
A Llera, M Brammer, B Oakley, J Tillmann, M Zabihi, JS Amelink, T Mei, T Charman, C Ecker, F Dell'Acqua, T Banaschewski, C Moessnang, S Baron-Cohen, R Holt, S Durston, D Murphy, E Loth, JK Buitelaar, DL Floris, CF Beckmann
Aug 16, 2022
An increasing number of large-scale multi-modal research initiatives has been conducted in the typically developing population, e.g. Dev. Cogn. Neur. 32:43-54, 2018; PLoS Med. 12(3):e1001779, 2015; Elam and Van Essen, Enc. Comp....
Unique dynamic profiles of social attention in autistic females.
The EU-AIMS Longitudinal European Autism Project (LEAP)
Tony Charman, Eva Loth, Julian Tillmann, Daisy Crawley, Caroline Wooldridge, David Goyard, Jumana Ahmad, Bonnie Auyeung, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Sven Bölte, Thomas Bourgeron, Carsten Bours, Michael Brammer, Daniel Brandeis, Claudia Brogna, Yvette de Bruijn, Bhismadev Chakrabarti, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garcés, Lindsay Ham, Hannah Hayward, Joerg Hipp, Rosemary Holt, Johan Isaksson, Mark Johnson, Emily JH Jones, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Luke Mason, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Barbara Ruggeri, Amber Ruigrok, Jessica Sabet, Roberto Sacco, Antonia San Jóse Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve CR Williams, Marcel P Zwiers, Will Spooren, Declan GM Murphy, Jan K Buitelaar
Aug 18, 2017
Humans Severity of Illness Index Longitudinal Studies Impulsive Behavior Individuality Parents Age Factors Sex Factors Phenotype Genetic Heterogeneity Adolescent Adult Child Female Male Self Report Biomarkers Surveys and Questionnaires Autism spectrum disorder
Published by: Molecular autism
The EU-AIMS Longitudinal European Autism Project (LEAP)
Eva Loth, Tony Charman, Luke Mason, Julian Tillmann, Emily JH Jones, Caroline Wooldridge, Jumana Ahmad, Bonnie Auyeung, Claudia Brogna, Sara Ambrosino, Tobias Banaschewski, Simon Baron-Cohen, Sarah Baumeister, Christian Beckmann, Michael Brammer, Daniel Brandeis, Sven Bölte, Thomas Bourgeron, Carsten Bours, Yvette de Bruijn, Bhismadev Chakrabarti, Daisy Crawley, Ineke Cornelissen, Flavio Dell' Acqua, Guillaume Dumas, Sarah Durston, Christine Ecker, Jessica Faulkner, Vincent Frouin, Pilar Garces, David Goyard, Hannah Hayward, Lindsay M Ham, Joerg Hipp, Rosemary Holt, Mark Johnson, Johan Isaksson, Prantik Kundu, Meng-Chuan Lai, Xavier Liogier D'ardhuy, Michael V Lombardo, David J Lythgoe, René Mandl, Andreas Meyer-Lindenberg, Carolin Moessnang, Nico Mueller, Laurence O'Dwyer, Marianne Oldehinkel, Bob Oranje, Gahan Pandina, Antonio M Persico, Amber Ruigrok, Barbara Ruggeri, Jessica Sabet, Roberto Sacco, Antonia San José Cáceres, Emily Simonoff, Roberto Toro, Heike Tost, Jack Waldman, Steve CR Williams, Marcel P Zwiers, Will Spooren, Declan GM Murphy, Jan K Buitelaar
Aug 18, 2017
Brain Saliva Hair Humans Magnetic Resonance Imaging Longitudinal Studies Individuality Siblings Phenotype Genetic Heterogeneity Patient Selection Adult Child Female Male Eye Movement Measurements Neuroimaging Biomarkers Autism spectrum disorder Precision Medicine
Published by: Molecular autism
Resting state EEG power spectrum and functional connectivity in autism
Pilar Garcés, Sarah Baumeister, Luke Mason, Christopher H Chatham, Stefan Holiga, Juergen Dukart, Emily JH Jones, Tobias Banaschewski, Simon Baron-Cohen, Sven Bölte, Jan K Buitelaar, Sarah Durston, Bob Oranje, Antonio M Persico, Christian F Beckmann, Thomas Bougeron, Flavio Dell'Acqua, Christine Ecker, Carolin Moessnang, Tony Charman, Julian Tillmann, Declan GM Murphy, Mark Johnson, Eva Loth, Daniel Brandeis, Joerg F Hipp, EU-AIMS LEAP group authorship
Jun 29, 2022
BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a...
Social brain activation during mentalizing in a large autism cohort
Carolin Moessnang, Sarah Baumeister, Julian Tillmann, David Goyard, Tony Charman, Sara Ambrosino, Simon Baron-Cohen, Christian Beckmann, Sven Bölte, Carsten Bours, Daisy Crawley, Flavio Dell'Acqua, Sarah Durston, Christine Ecker, Vincent Frouin, Hannah Hayward, Rosemary Holt, Mark Johnson, Emily Jones, Meng-Chuan Lai, Michael V Lombardo, Luke Mason, Marianne Oldenhinkel, Antonio Persico, Antonia San José Cáceres, Will Spooren, Eva Loth, Declan GM Murphy, Jan K Buitelaar, Tobias Banaschewski, Daniel Brandeis, Heike Tost, Andreas Meyer-Lindenberg, EU-AIMS LEAP group
Mar 09, 2020
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition with key deficits in social functioning. It is widely assumed that the biological underpinnings of social impairment are neurofunctional alterations in...
Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder
J Tillmann, M Uljarevic, D Crawley, G Dumas, E Loth, D Murphy, J Buitelaar, T Charman, AIMS-2-TRIALS LEAP group
Oct 26, 2020
BACKGROUND: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a...
Fractionating autism based on neuroanatomical normative modeling.
Mariam Zabihi, Dorothea L Floris, Seyed Mostafa Kia, Thomas Wolfers, Julian Tillmann, Alberto Llera Arenas, Carolin Moessnang, Tobias Banaschewski, Rosemary Holt, Simon Baron-Cohen, Eva Loth, Tony Charman, Thomas Bourgeron, Declan Murphy, Christine Ecker, Jan K Buitelaar, Christian F Beckmann, Andre Marquand, EU-AIMS LEAP group
Jun 07, 2022
The two faces of EU–NATO cooperation
Maritime engagement in the Gulf of Aden is a puzzling case for anyone interested in the political and institutional problems underlying European Union–North Atlantic Treaty Organization (EU–NATO) cooperation. Although the EU’s...
The two faces of EU–NATO cooperation
Maritime engagement in the Gulf of Aden is a puzzling case for anyone interested in the political and institutional problems underlying European Union–North Atlantic Treaty Organization (EU–NATO) cooperation. Although the EU’s...
Resting state EEG power spectrum and functional connectivity in autism
Pilar Garcés, Sarah Baumeister, Luke Mason, Christopher H Chatham, Stefan Holiga, Juergen Dukart, Emily JH Jones, Tobias Banaschewski, Simon Baron-Cohen, Sven Bölte, Jan K Buitelaar, Sarah Durston, Bob Oranje, Antonio M Persico, Christian F Beckmann, Thomas Bougeron, Flavio Dell'Acqua, Christine Ecker, Carolin Moessnang, Tony Charman, Julian Tillmann, Declan GM Murphy, Mark Johnson, Eva Loth, Daniel Brandeis, Joerg F Hipp, EU-AIMS LEAP group authorship
May 19, 2022
BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a...
EU Enlargement Rounds and Dilemmas
Dorian Jano
Jan 21, 2022
This chapter adopts both a historical and a comparative approach in studying EU enlargement. The aim here is to identify ‘whether' and ‘when' a country joins the Union, with an emphasis on the currently ongoing enlargement...
Published by: IGI Global Scientific Publishing
Towards robust and replicable sex differences in the intrinsic brain function of autism.
Dorothea L Floris, José OA Filho, Meng-Chuan Lai, Steve Giavasis, Marianne Oldehinkel, Maarten Mennes, Tony Charman, Julian Tillmann, Guillaume Dumas, Christine Ecker, Flavio Dell'Acqua, Tobias Banaschewski, Carolin Moessnang, Simon Baron-Cohen, Sarah Durston, Eva Loth, Declan GM Murphy, Jan K Buitelaar, Christian F Beckmann, Michael P Milham, Adriana Di Martino
Apr 12, 2021
BACKGROUND: Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have...
Pro-Environmental Behaviour of EU Citizens
This article examines the pro-environmental behaviour of EU citizens and the potential connection with their attitudes towards common environmental legislation and environmental standards. It analyses factors of the...
IT Policy & Standardization Computer Science and Information Technology IT Policy and Standardization
Published by: IGI Global Scientific Publishing
The Max-Min Group Contest
We investigate a group all-pay auction in which each group's effort is represented by the minimum among the effort levels exerted by the group members and the prize is a group-specific public good. We fully characterize the...
Genetic correlates of phenotypic heterogeneity in autism.
Varun Warrier, Xinhe Zhang, Patrick Reed, Alexandra Havdahl, Tyler M Moore, Freddy Cliquet, Claire S Leblond, Thomas Rolland, Anders Rosengren, EU-AIMS LEAP, iPSYCH-Autism Working Group, Spectrum 10K and APEX Consortia, David H Rowitch, Matthew E Hurles, Daniel H Geschwind, Anders D Børglum, Elise B Robinson, Jakob Grove, Hilary C Martin, Thomas Bourgeron, Simon Baron-Cohen
Sep 13, 2022
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