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A comparison over 2 decades of disability-free life expectancy at age 65 years for those with long-term conditions in England
Holly Q Bennett, Andrew Kingston, Ilianna Lourida, Louise Robinson, Lynne Corner, Carol Brayne, Fiona E Matthews, Carol Jagger, Cognitive Function and Ageing Studies collaboration
Mar 15, 2022
BACKGROUND: Previous research has examined the improvements in healthy years if different health conditions are eliminated, but often with cross-sectional data, or for a limited number of conditions. We used longitudinal data to...
A comparison over 2 decades of disability-free life expectancy at age 65 years for those with long-term conditions in England
Holly Q Bennett, Andrew Kingston, Ilianna Lourida, Louise Robinson, Lynne Corner, Carol Brayne, Fiona E Matthews, Carol Jagger, Cognitive Function and Ageing Studies collaboration
Apr 19, 2022
BACKGROUND: Previous research has examined the improvements in healthy years if different health conditions are eliminated, but often with cross-sectional data, or for a limited number of conditions. We used longitudinal data to...
A comparison of health expectancies over two decades in England
Carol Jagger, Fiona E Matthews, Pia Wohland, Tony Fouweather, Blossom CM Stephan, Louise Robinson, Antony Arthur, Carol Brayne, Medical Research Council Cognitive Function and Ageing Collaboration
Nov 09, 2018
BACKGROUND: Whether rises in life expectancy are increases in good-quality years is of profound importance worldwide, with population ageing. We investigate how various health expectancies have changed in England between 1991...
Two-decade change in prevalence of cognitive impairment in the UK.
Connor Richardson, Blossom CM Stephan, Louise Robinson, Carol Brayne, Fiona E Matthews, Cognitive Function and Ageing Study Collaboration
Sep 04, 2020
Identification of individuals at high risk of dementia has usually focused attention on the clinical concept of mild cognitive impairment (MCI), which captures an intermediate state between normal cognitive ageing and dementia....
Dementia before death in ageing societies--the promise of prevention and the reality.
Carol Brayne, Lu Gao, Michael Dewey, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Study Investigators
Jul 10, 2018
BACKGROUND: Dementia and severe cognitive impairment are very closely linked to ageing. The longer we live the more likely we are to suffer from these conditions. Given population increases in longevity it is important to...
Cohort differences in disease and disability in the young-old
Carol Jagger, Ruth J Matthews, Fiona E Matthews, Nicola A Spiers, Judith Nickson, Eugene S Paykel, Felicia A Huppert, Carol Brayne, Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS)
Jun 14, 2011
BACKGROUND: Projections of health and social care need are highly sensitive to assumptions about cohort trends in health and disability. We use a repeated population-based cross-sectional study from the Cambridgeshire centre of...
Accuracy of death certification of dementia in population-based samples of older people
Lu Gao, Rowan Calloway, Emily Zhao, Carol Brayne, Fiona E Matthews, Medical Research Council Cognitive Function and Ageing Collaboration
Jul 10, 2018
BACKGROUND: death certification data are routinely collected in most developed countries. Coded causes of death are a readily accessible source and have the potential advantage of providing complete follow-up, but with...
Who Lives Where and Does It Matter? Changes in the Health Profiles of Older People Living in Long Term Care and the Community over Two Decades in a High Income Country.
Epidemiological pathology of Aβ deposition in the ageing brain in CFAS
SB Wharton, D Wang, C Parikh, FE Matthews, C Brayne, Pg Ince, Cognitive Function and Ageing Neuropathology Study Group
Jan 10, 2020
Aβ-amyloid deposition is a key feature of Alzheimer's disease, but Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, based on neuritic plaque density, shows a limited relationships to dementia. Thal...
APOE and ACE polymorphisms and dementia risk in the older population over prolonged follow-up
HAD Keage, FE Matthews, A Yip, L Gao, C McCracken, IG McKeith, DC Rubinsztein, C Brayne, MRC Cognitive Function and Ageing Study
Jul 10, 2018
BACKGROUND: dementia risk conferred by apolipoprotein-E (APOE) and angiotensin-1-converting enzyme (ACE) polymorphisms have been reported for the MRC Cognitive Function and Ageing Study (CFAS) at 6-year follow-up. We concentrate...
Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain.
Joanna J Bury, Annabelle Chambers, Paul R Heath, Paul G Ince, Pamela J Shaw, Fiona E Matthews, Carol Brayne, Julie E Simpson, Stephen B Wharton, Cognitive Function and Ageing Study
Jan 27, 2021
Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain...
Microinfarcts in an older population-representative brain donor cohort (MRC CFAS)
Pg Ince, T Minett, G Forster, C Brayne, SB Wharton, Medical Research Council Cognitive Function and Ageing Neuropathology Study
Aug 13, 2018
INTRODUCTION: Microinfarcts, small ischaemic foci common in ageing brain, are associated with dementia and gait dysfunction. We determined their relationship with dementia, mobility and cerebrovascular disease in an older...
Assessment of Alzheimer-related pathologies of dementia using machine learning feature selection.
Mohammed D Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E Matthews, Li Su, Paul G Ince, Stephen B Wharton, Dennis Wang, Cognitive Function and Ageing Neuropathology Study Group
Mar 10, 2023
Although a variety of brain lesions may contribute to the pathological assessment of dementia, the relationship of these lesions to dementia, how they interact and how to quantify them remains uncertain. Systematically assessing...
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology.
Julie E Simpson, Paul G Ince, Thais Minett, Fiona E Matthews, Paul R Heath, Pamela J Shaw, Emily Goodall, Claire J Garwood, Laura E Ratcliffe, Carol Brayne, Magnus Rattray, Stephen B Wharton, MRC Cognitive Function and Ageing Neuropathology Study Group
Aug 09, 2018
AIMS: Oxidative damage and an associated DNA damage response (DDR) are evident in mild cognitive impairment and early Alzheimer's disease, suggesting that neuronal dysfunction resulting from oxidative DNA damage may account for...
Ageing brain Alzheimer's DNA damage response Dementia microarray neurones Aged 80 and over aging Alzheimer Disease Blotting Western Brain Cholesterol DNA Damage Female Humans Immunohistochemistry Laser Capture Microdissection Male Neurons Oligonucleotide Array Sequence Analysis Real-Time Polymerase Chain Reaction Signal Transduction Transcriptome
Regional differences in multidimensional aspects of health
Fiona E Matthews, Laura L Miller, Carol Brayne, Carol Jagger, Medical Research Council Cognitive Function and Aging Study (MRC CFAS)
Jun 16, 2011
Activities of Daily Living Aged Aged 80 and over Attitude to Health Cognition Disorders Cohort Studies Female Geography Geriatric Assessment Health Surveys Humans Life Change Events Life Expectancy Male Prospective Studies Quality of life Rural Health Self Concept Socioeconomic Factors United Kingdom Urban Health
Population-Based Studies in Dementia and Ageing Research
Dementia has been recognised as a key challenge in many ageing societies across the world. Several population-based studies have been developed to investigate dementia and cognitive ageing from perspectives of biology, health...
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