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Results: 17
Association of genetically predicted testosterone with thromboembolism, heart failure, and myocardial infarction
OBJECTIVE: To determine whether endogenous testosterone has a causal role in thromboembolism, heart failure, and myocardial infarction. DESIGN: Two sample mendelian randomisation study using genetic variants as instrumental...
Adult Aged Biological Specimen Banks Female Genetic Pleiotropy genetic variation Genome-Wide Association Study Heart Failure Humans Male Mendelian Randomization Analysis Middle Aged Myocardial Infarction Odds Ratio Randomized Controlled Trials as Topic Risk Factors Testosterone Thromboembolism United Kingdom White People
Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk
Ingrid Brænne, Lingyao Zeng, Christina Willenborg, Vinicius Tragante, Thorsten Kessler, CARDIoGRAM consortium, CARDIoGRAMplusC4D Consortium, Cristen J Willer, Markku Laakso, Lars Wallentin, Paul W Franks, Veikko Salomaa, Abbas Dehghan, Thomas Meitinger, Nilesh J Samani, Folkert W Asselbergs, Jeanette Erdmann, Heribert Schunkert
Jan 25, 2018
Genetic predisposition to smoking in relation to 14 cardiovascular diseases.
Susanna C Larsson, Amy M Mason, Magnus Bäck, Derek Klarin, Scott M Damrauer, Million Veteran Program, Karl Michaëlsson, Stephen Burgess
May 05, 2020
AIMS: The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs). METHODS AND RESULTS: Our primary genetic...
cardiovascular disease lifestyle Mendelian randomization Risk Factors SINGLE-NUCLEOTIDE POLYMORPHISMS Smoking Brain Ischemia Cardiovascular Diseases Genetic Predisposition to Disease Genome-Wide Association Study Humans Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors Smoking stroke
Mendelian Randomisation study of the influence of eGFR on coronary heart disease.
Pimphen Charoen, Dorothea Nitsch, Jorgen Engmann, Tina Shah, Jonathan White, Delilah Zabaneh, Barbara Jefferis, Goya Wannamethee, Peter Whincup, Amy Mulick Cassidy, Tom Gaunt, Ian Day, Stela McLachlan, Jacqueline Price, Meena Kumari, Mika Kivimaki, Eric Brunner, Claudia Langenberg, Yoav Ben-Shlomo, Aroon Hingorani, John Whittaker, Juan Pablo Casas, Frank Dudbridge, UCLEB Consortium
Sep 09, 2016
Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this...
Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases
Shuai Yuan, Magnus Bäck, Maria Bruzelius, Amy M. Mason, Stephen Burgess, Susanna Larsson
Dec 10, 2019
Whether circulating fatty acids (FAs) play a causal role in the development of cardiovascular disease (CVD) remains unclear. We conducted a Mendelian randomisation study to explore the associations between plasma phospholipid FA...
Serum magnesium levels and risk of coronary artery disease
Background. Observational studies have shown that serum magnesium levels are inversely associated risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomization study to...
Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk
Dipender Gill, Marios K Georgakis, Verena Zuber, Ville Karhunen, Stephen Burgess, Rainer Malik, Martin Dichgans
Jun 02, 2020
Background Elevated blood pressure is a major cause of cardiovascular morbidity and mortality. However, it is not known whether midlife blood pressure affects later life cardiovascular risk independent of later life blood...
Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease
Shuai Yuan, Stephen Burgess, Mike Laffan, Amy M Mason, Martin Dichgans, Dipender Gill, Susanna C Larsson
Feb 19, 2021
Background We conducted Mendelian randomization analyses investigating the linear associations of genetically proxied inhibition of different coagulation factors with risk of common cardiovascular diseases. Methods and Results...
Mendelian Randomization Analysis cardiovascular disease Coagulation stroke venous thromboembolism Blood Coagulation Factors Cardiovascular Diseases Genetic Predisposition to Disease Genome-Wide Association Study Humans Japan Mendelian Randomization Analysis Polymorphism Single Nucleotide Risk Factors
Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults.
Tibor V Varga, Azra Kurbasic, Mattias Aine, Pontus Eriksson, Ashfaq Ali, George Hindy, Stefan Gustafsson, Jian'an Luan, Dmitry Shungin, Yan Chen, Christina-Alexandra Schulz, Peter M Nilsson, Göran Hallmans, Inês Barroso, Panos Deloukas, Claudia Langenberg, Robert A Scott, Nicholas J Wareham, Lars Lind, Erik Ingelsson, Olle Melander, Marju Orho-Melander, Frida Renström, Paul W Franks
Aug 15, 2017
BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes...
Prospective cohort study Genetic epidemiology longitudinal analysis Morbidity single nucleotide polymorphism Total cholesterol Triglycerides Adult Aged Coronary Artery Disease Cross-Sectional Studies Female Genetic Loci Genome-Wide Association Study Genotype Humans Lipids Male Meta-Analysis as Topic Middle Aged Polymorphism Single Nucleotide Prospective Studies Sweden White People
Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases
Killian Donovan, William G Herrington, Guillaume Paré, Marie Pigeyre, Richard Haynes, Rebecca Sardell, Adam S Butterworth, Lasse Folkersen, Stefan Gustafsson, Qin Wang, Colin Baigent, Anders Mälarstig, Michael V Holmes, Natalie Staplin, on behalf of the SCALLOP Consortium
Mar 03, 2023
BACKGROUND: Fibroblast growth factor-23 (FGF-23) is associated with a range of cardiovascular and noncardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian...
Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors
C Mary Schooling, Shan Luo, Shiu Lun Au Yeung, Deborah J Thompson, Savita Karthikeyan, Thomas R Bolton, Amy M Mason, Erik Ingelsson, Stephen Burgess
Sep 08, 2018
BACKGROUND: Testosterone supplementation has been linked to increased cardiovascular disease risk in some observational studies. The causal role of testosterone can be investigated using a Mendelian randomization approach....
causal inference Disease aetiology Genetic epidemiology Mendelian randomization sex hormones Testosterone Adiponectin Aged Anthropometry blood pressure Coronary Artery Disease Genetic Predisposition to Disease genetic variation Genome-Wide Association Study Humans Jumonji Domain-Containing Histone Demethylases Lipids Male Mendelian Randomization Analysis Middle Aged Oxidoreductases N-Demethylating Receptors Cell Surface Risk Factors stroke Testosterone United Kingdom United States
Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease
Danish Saleheen, Philip C Haycock, Wei Zhao, Asif Rasheed, Adam Taleb, Atif Imran, Shahid Abbas, Faisal Majeed, Saba Akhtar, Nadeem Qamar, Khan Shah Zaman, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Nadeem Hayyat Mallick, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Khalid Mahmood, Naveeduddin Ahmed, Philippe Frossard, Sotirios Tsimikas, Joseph L Witztum, Santica Marcovina, Manjinder Sandhu, Daniel J Rader, John Danesh
Nov 15, 2017
BACKGROUND: The lipoprotein(a) pathway is a causal factor in coronary heart disease. We used a genetic approach to distinguish the relevance of two distinct components of this pathway, apolipoprotein(a) isoform size and...
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease
Tom G Richardson, Eleanor Sanderson, Tom M Palmer, Mika Ala-Korpela, Brian A Ference, George Davey Smith, Michael V Holmes
Apr 24, 2020
BACKGROUND: Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic...
Adult Aged Apolipoprotein A-I Apolipoprotein B-100 Biomarkers Cholesterol HDL Cholesterol LDL Coronary Disease Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Mendelian Randomization Analysis Middle Aged Multivariate Analysis Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Triglycerides
Association analyses based on false discovery rate implicate new loci for coronary artery disease
CP Nelson, A Goel, AS Butterworth, S Kanoni, TR Webb, E Marouli, L Zeng, I Ntalla, FY Lai, JC Hopewell, O Giannakopoulou, T Jiang, SE Hamby, E Di Angelantonio, TL Assimes, EP Bottinger, JC Chambers, R Clarke, CNA Palmer, RM Cubbon, P Ellinor, R Ermel, E Evangelou, PW Franks, C Grace, D Gu, AD Hingorani, JMM Howson, E Ingelsson, A Kastrati, T Kessler, T Kyriakou, T Lehtimäki, X Lu, Y Lu, W März, R McPherson, A Metspalu, M Pujades-Rodriguez, A Ruusalepp, EE Schadt, AF Schmidt, MJ Sweeting, PA Zalloua, K AlGhalayini, BD Keavney, JS Kooner, RJF Loos, RS Patel, MK Rutter, M Tomaszewski, I Tzoulaki, E Zeggini, J Erdmann, G Dedoussis, JLM Björkegren, EPIC-CVD Consortium, CARDIoGRAMplusC4D, UK Biobank CardioMetabolic Consortium CHD working group, H Schunkert, M Farrall, J Danesh, NJ Samani, H Watkins, P Deloukas
Aug 21, 2017
Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms
JMM Howson, W Zhao, DR Barnes, W-K Ho, R Young, DS Paul, LL Waite, DF Freitag, EB Fauman, EL Salfati, BB Sun, JD Eicher, AD Johnson, WHH Sheu, SF Nielsen, W-Y Lin, P Surendran, A Malarstig, JB Wilk, A Tybjaerg-Hansen, KL Rasmussen, PR Kamstrup, P Deloukas, J Erdmann, S Kathiresan, NJ Samani, H Schunkert, H Watkins, CARDIoGRAMplusC4D, R Do, DJ Rader, JA Johnson, SL Hazen, AA Quyyumi, JA Spertus, CJ Pepine, N Franceschini, A Justice, AP Reiner, S Buyske, LA Hindorff, CL Carty, KE North, C Kooperberg, E Boerwinkle, K Young, M Graff, U Peters, D Absher, CA Hsiung, W-J Lee, KD Taylor, Y-H Chen, I-T Lee, X Guo, R-H Chung, Y-J Hung, JI Rotter, J-MJ Juang, T Quertermous, T-D Wang, A Rasheed, P Frossard, DS Alam, AAS Majumder, E Di Angelantonio, R Chowdhury, EPIC-CVD, Y-DI Chen, BG Nordestgaard, TL Assimes, J Danesh, AS Butterworth, D Saleheen
Aug 25, 2017
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes
BP Prins, A Abbasi, A Wong, A Vaez, I Nolte, N Franceschini, PE Stuart, J Guterriez Achury, V Mistry, JP Bradfield, AM Valdes, J Bras, A Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, C Lu, B Han, S Raychaudhuri, S Bevan, MD Mayes, LC Tsoi, E Evangelou, RP Nair, SFA Grant, C Polychronakos, TRD Radstake, DA van Heel, ML Dunstan, NW Wood, A Al-Chalabi, A Dehghan, H Hakonarson, HS Markus, JT Elder, J Knight, DE Arking, TD Spector, BPC Koeleman, CM van Duijn, J Martin, AP Morris, RK Weersma, C Wijmenga, PB Munroe, JRB Perry, JG Pouget, Y Jamshidi, H Snieder, BZ Alizadeh
Jan 30, 2017
BACKGROUND: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. METHODS AND FINDINGS: We performed Mendelian...
Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants.
Krishna G Aragam, Tao Jiang, Anuj Goel, Stavroula Kanoni, Brooke N Wolford, Deepak S Atri, Elle M Weeks, Minxian Wang, George Hindy, Wei Zhou, Christopher Grace, Carolina Roselli, Nicholas A Marston, Frederick K Kamanu, Ida Surakka, Loreto Muñoz Venegas, Paul Sherliker, Satoshi Koyama, Kazuyoshi Ishigaki, Bjørn O Åsvold, Michael R Brown, Ben Brumpton, Paul S de Vries, Olga Giannakopoulou, Panagiota Giardoglou, Daniel F Gudbjartsson, Ulrich Güldener, Syed M Ijlal Haider, Anna Helgadottir, Maysson Ibrahim, Adnan Kastrati, Thorsten Kessler, Theodosios Kyriakou, Tomasz Konopka, Ling Li, Lijiang Ma, Thomas Meitinger, Sören Mucha, Matthias Munz, Federico Murgia, Jonas B Nielsen, Markus M Nöthen, Shichao Pang, Tobias Reinberger, Gavin Schnitzler, Damian Smedley, Gudmar Thorleifsson, Moritz von Scheidt, Jacob C Ulirsch, Biobank Japan, EPIC-CVD, David O Arnar, Noël P Burtt, Maria C Costanzo, Jason Flannick, Kaoru Ito, Dong-Keun Jang, Yoichiro Kamatani, Amit V Khera, Issei Komuro, Iftikhar J Kullo, Luca A Lotta, Christopher P Nelson, Robert Roberts, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Thomas R Webb, Aris Baras, Johan LM Björkegren, Eric Boerwinkle, George Dedoussis, Hilma Holm, Kristian Hveem, Olle Melander, Alanna C Morrison, Marju Orho-Melander, Loukianos S Rallidis, Arno Ruusalepp, Marc S Sabatine, Kari Stefansson, Pierre Zalloua, Patrick T Ellinor, Martin Farrall, John Danesh, Christian T Ruff, Hilary K Finucane, Jemma C Hopewell, Robert Clarke, Rajat M Gupta, Jeanette Erdmann, Nilesh J Samani, Heribert Schunkert, Hugh Watkins, Cristen J Willer, Panos Deloukas, Sekar Kathiresan, Adam S Butterworth, CARDIoGRAMplusC4D Consortium
Jan 06, 2023
The discovery of genetic loci associated with complex diseases has outpaced the elucidation of mechanisms of disease pathogenesis. Here we conducted a genome-wide association study (GWAS) for coronary artery disease (CAD)...