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Results: 68
Decision Support for Plan Adaptation in Unforeseen Situations
Handling irregular phenomena might bring great complexity for involved teams. Variables considered for undertaking recommended procedures may yield many decision alternatives, which is challenging to deal with at planning time....
Published by: IGI Global Scientific Publishing
Mate retention Strategies, Self-Esteem, Mate Value and Facial Attractiveness Disparity in Brazil and in the UK
This study compared mate retention strategies (MRS) in Brazil and in the UK, testing whether culture moderates the association between MRS and self-evaluated variables (e.g. mate value). Our findings demonstrated that women’s...
Mate retention Strategies, Self-Esteem, Mate Value and Facial Attractiveness Disparity in Brazil and in the UK
This study compared mate retention strategies (MRS) in Brazil and in the UK, testing whether culture moderates the association between MRS and self-evaluated variables (e.g. mate value). Our findings demonstrated that women’s...
Metabolic imaging with hyperpolarized [1-13C] pyruvate in patient-derived preclinical mouse models of breast cancer.
13C nuclear spin hyperpolarization can increase the sensitivity of detection in an MRI experiment by more than 10,000-fold. 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between...
Psychoneuroendocrine interventions aimed at attenuating immunosenescence
Moisés E Bauer, Guilherme C Muller, Bruna Luz Correa, Priscila Vianna, James E Turner, Jos A Bosch
Feb 01, 2013
There is evidence suggesting that immunosenescence can be accelerated by external factors such as chronic stress. Here we review potential psychoneuroendocrine determinants of premature aging of the immune system and discuss...
SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis.
Stephin J Vervoort, Ana Rita Lourenço, Ana Tufegdzic Vidakovic, Enric Mocholi, José L Sandoval, Oscar M Rueda, Cynthia Frederiks, Cornelieke Pals, Janneke GC Peeters, Carlos Caldas, Alejandra Bruna, Paul J Coffer
Dec 13, 2018
Expression of the transcription factor SOX4 is often elevated in human cancers, where it generally correlates with tumor-progression and poor-disease outcome. Reduction of SOX4 expression results in both diminished...
Indigenous and local communities can boost seed supply in the UN decade on ecosystem restoration.
Exploitation of an ancestral pheromone biosynthetic pathway contributes to diversification in <i>Heliconius</i> butterflies.
Bruna Cama, Stephanie Ehlers, Daiane Szczerbowski, Jane Thomas-Oates, Chris D Jiggins, Stefan Schulz, W Owen McMillan, Kanchon K Dasmahapatra
Sep 02, 2022
reproductive isolation chemical ecology sympatric speciation macroevolution Animals Butterflies Pheromones Sex Attractants Female Male Biosynthetic Pathways Sympatry
Published by: Proceedings. Biological sciences
Psychoneuroendocrine interventions aimed at attenuating immunosenescence
Moisés E Bauer, Guilherme C Muller, Bruna Luz Correa, Priscila Vianna, James E Turner, Jos A Bosch
Feb 01, 2013
There is evidence suggesting that immunosenescence can be accelerated by external factors such as chronic stress. Here we review potential psychoneuroendocrine determinants of premature aging of the immune system and discuss...
Graphene-based mid-infrared room-temperature pyroelectric bolometers with ultrahigh temperature coefficient of resistance.
U Sassi, R Parret, S Nanot, M Bruna, S Borini, D De Fazio, Z Zhao, E Lidorikis, FHL Koppens, AC Ferrari, A Colli
Jan 12, 2018
There is a growing number of applications demanding highly sensitive photodetectors in the mid-infrared. Thermal photodetectors, such as bolometers, have emerged as the technology of choice, because they do not need cooling. The...
Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome.
Ana Tufegdzic Vidakovic, Oscar M Rueda, Stephin J Vervoort, Ankita Sati Batra, Mae Akilina Goldgraben, Santiago Uribe-Lewis, Wendy Greenwood, Paul J Coffer, Alejandra Bruna, Carlos Caldas
Oct 21, 2015
Binding Sites Cell Line Tumor DNA DNA Methylation Epigenesis Genetic Histones Humans Neoplastic Stem Cells Promoter Regions Genetic Protein Binding RNA Interference RNA Small Interfering Signal Transduction Smad2 Protein Smad3 Protein Trans-Activators Transcription Factors Transforming Growth Factor beta
Intersect-then-combine approach
Maurizio Callari, Stephen-John Sammut, Leticia De Mattos-Arruda, Alejandra Bruna, Oscar M Rueda, Suet-Feung Chin, Carlos Caldas
May 05, 2017
Bioinformatic analysis of genomic sequencing data to identify somatic mutations in cancer samples is far from achieving the required robustness and standardisation. In this study we generated a whole exome sequencing benchmark...
BWA Filtering Mutect2 NA12878 Novoalign Platinum genome Somatic mutation Strelka Variant calling Whole exome sequencing Algorithms Computational Biology DNA Neoplasm Exome Genome Human Humans INDEL Mutation Mutation Neoplasms Polymorphism Single Nucleotide Sensitivity and Specificity Sequence Analysis DNA
Liquid-Phase Exfoliation of Graphite into Single- and Few-Layer Graphene with α-Functionalized Alkanes.
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
Zheng Xue, Daniel J Vis, Alejandra Bruna, Tonci Sustic, Sake van Wageningen, Ankita Sati Batra, Oscar M Rueda, Evert Bosdriesz, Carlos Caldas, Lodewyk FA Wessels, René Bernards
Apr 29, 2019
Activation of the mitogen-activated protein kinase (MAPK) pathway is frequent in cancer. Drug development efforts have been focused on kinases in this pathway, most notably on RAF and MEK. We show here that MEK inhibition...
Animals Benzimidazoles Breast Neoplasms Cell Line Tumor Colonic Neoplasms Drug Resistance Neoplasm Female Heterografts Humans Loss of Function Mutation MAP Kinase Kinase 4 MAP Kinase Kinase Kinase 1 MAP Kinase Signaling System Male Mice Inbred BALB C Mice Nude Mitogen-Activated Protein Kinase Kinases Prostatic Neoplasms Protein Kinase Inhibitors
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis- regulation
Rajbir Nath Batra, Aviezer Lifshitz, Ana Tufegdzic Vidakovic, Suet-Feung Chin, Ankita Sati-Batra, Stephen-John Sammut, Elena Provenzano, H. Raza Ali, Ali Dariush, Alejandra Bruna, Leigh Murphy, Arnie Purushotham, Ian Ellis, Andrew Green, Francine E. Garrett-Bakelman, Chris Mason, Ari Melnick, Samuel A. J. R. Aparicio, Oscar M. Rueda, Amos Tanay, Carlos Caldas
Sep 13, 2021
Landscape of G-quadruplex DNA structural regions in breast cancer.
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