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Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes.
Elżbieta Niechciał, Carlo L Acerini, Scott T Chiesa, Tracey Stevens, R Neil Dalton, Denis Daneman, John E Deanfield, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, M Loredana Marcovecchio, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group, Adolescent Type 1 Diabetes Cardio-renal Intervention Trial AdDIT Study Group
Jan 31, 2020
OBJECTIVE: Suboptimal adherence to insulin treatment is a main issue in adolescents with type 1 diabetes. However, to date, there are no available data on adherence to adjunct noninsulin medications in this population. Our aim...
Adolescent Angiotensin-Converting Enzyme Inhibitors Australia Canada Cardiovascular Diseases Chemotherapy Adjuvant Child Diabetes mellitus Type 1 Diabetic Angiopathies Double-Blind Method Drug Therapy Combination Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Insulin Male Medication Adherence United Kingdom
Adolescent type 1 Diabetes Cardio-renal Intervention Trial (AdDIT).
Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors Area Under Curve Atorvastatin Biomarkers Cardiomyopathies Diabetes mellitus Type 1 Diabetic Nephropathies Double-Blind Method Drug Therapy Combination Dyslipidemias Female Follow-Up Studies Heptanoic Acids Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Multicenter Studies as Topic Puberty Pyrroles Quinapril Randomized Controlled Trials as Topic Research Design risk Tetrahydroisoquinolines
Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes.
Scott T Chiesa, M Loredana Marcovecchio, Paul Benitez-Aguirre, Fergus J Cameron, Maria E Craig, Jennifer J Couper, Elizabeth A Davis, R Neil Dalton, Denis Daneman, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, David B Dunger, John E Deanfield, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Nov 03, 2020
An increased albumin-creatinine ratio within the normal range can identify adolescents at higher risk of developing adverse cardio-renal outcomes as they progress into adulthood. Utilizing a parallel randomized controlled trial...
Adolescent arteries Diabetes Type 1 Puberty Vascular diseases Adolescent Albuminuria Angiotensin-Converting Enzyme Inhibitors C-Reactive Protein Creatinine Diabetes mellitus Type 1 Double-Blind Method Drug Therapy Combination Endothelium Vascular Female Glycated Hemoglobin Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipids Male Pulse Wave Analysis Vascular Stiffness
Renal and Cardiovascular Risk According to Tertiles of Urinary Albumin-to-Creatinine Ratio
A new strategy for vascular complications in young people with type 1 diabetes mellitus.
M Loredana Marcovecchio, R Neil Dalton, Denis Daneman, John Deanfield, Timothy W Jones, H Andrew W Neil, David B Dunger, Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT) Study Group
Apr 16, 2019
Diabetes vascular complications, including cardiovascular disease, diabetic nephropathy and retinopathy, have a negative effect on the long-term prognosis of young people with type 1 diabetes mellitus (T1DM). Poor glycaemic...
Cardiac autonomic dysfunction is associated with high-risk albumin-to-creatinine ratio in young adolescents with type 1 diabetes in AdDIT (adolescent type 1 diabetes cardio-renal interventional trial).
ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes.
M Loredana Marcovecchio, Scott T Chiesa, Simon Bond, Denis Daneman, Sarah Dawson, Kim C Donaghue, Timothy W Jones, Farid H Mahmud, Sally M Marshall, H Andrew W Neil, R Neil Dalton, John Deanfield, David B Dunger, AdDIT Study Group
Jul 10, 2017
BACKGROUND: Among adolescents with type 1 diabetes, rapid increases in albumin excretion during puberty precede the development of microalbuminuria and macroalbuminuria, long-term risk factors for renal and cardiovascular...
Comparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes.
Marco Colombo, Stuart J McGurnaghan, Luke AK Blackbourn, R Neil Dalton, David Dunger, Samira Bell, John R Petrie, Fiona Green, Sandra MacRury, John A McKnight, John Chalmers, Andrew Collier, Paul M McKeigue, Helen M Colhoun, Scottish Diabetes Research Network (SDRN) Type 1 Bioresource Investigators
Jan 07, 2021
AIMS/HYPOTHESIS: We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary...
Clinical science EPIDEMIOLOGY Metabolomics Nephropathy Proteomics Adult Aged Albumins Albuminuria Biomarkers Blood Chemical Analysis Cohort Studies Creatinine Diabetes mellitus Type 1 Diabetic Nephropathies Diagnostic Techniques Endocrine Enzyme-Linked Immunosorbent Assay Female Humans Kidney Function Tests Male Middle Aged Prognosis Prospective Studies Scotland Serum Albumin Urinalysis
Multiple behaviour change intervention and outcomes in recently diagnosed type 2 diabetes
Simon J Griffin, Rebecca K Simmons, A Toby Prevost, Kate M Williams, Wendy Hardeman, Stephen Sutton, Søren Brage, Ulf Ekelund, Richard A Parker, Nicholas J Wareham, Ann Louise Kinmonth, ADDITION-Plus study team
Jun 13, 2018
AIMS/HYPOTHESIS: The aim of this study was to assess whether or not a theory-based behaviour change intervention delivered by trained and quality-assured lifestyle facilitators can achieve and maintain improvements in physical...
Confirmation of novel type 1 diabetes risk loci in families.
JD Cooper, JMM Howson, D Smyth, NM Walker, H Stevens, JHM Yang, J-X She, GS Eisenbarth, M Rewers, JA Todd, B Akolkar, P Concannon, HA Erlich, C Julier, G Morahan, J Nerup, C Nierras, F Pociot, SS Rich, Type 1 Diabetes Genetics Consortium
Jul 09, 2019
AIMS/HYPOTHESIS: Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were...
Lower plasma insulin levels during overnight closed-loop in school children with type 1 diabetes
Ulrike Schierloh, Malgorzata E Wilinska, Ineke M Pit-Ten Cate, Petra Baumann, Roman Hovorka, Carine de Beaufort, Spidiman Study Group: Single Port Insulin Infusion for Improved Diabetes Management
Mar 11, 2019
BACKGROUND: Studies have shown that overnight closed-loop insulin delivery can improve glucose control and reduce the risk of hypoglycemia and hence may improve metabolic outcomes and reduce burden for children with type 1...
Biomarker panels associated with progression of renal disease in type 1 diabetes.
AiDAPT: automated insulin delivery amongst pregnant women with type 1 diabetes
Tara TM Lee, Corinne Collett, Mei-See Man, Matt Hammond, Lee Shepstone, Sara Hartnell, Eleanor Gurnell, Caroline Byrne, Eleanor M Scott, Robert S Lindsay, Damian Morris, Anna Brackenridge, Anna R Dover, Rebecca M Reynolds, Katharine F Hunt, David R McCance, Katharine Barnard-Kelly, David Rankin, Julia Lawton, Laura E Bocchino, Judy Sibayan, Craig Kollman, Malgorzata E Wilinska, Roman Hovorka, Helen R Murphy, AiDAPT Collaborative Group
May 09, 2022
BACKGROUND: Pregnant women with type 1 diabetes strive for tight glucose targets (3.5-7.8 mmol/L) to minimise the risks of obstetric and neonatal complications. Despite using diabetes technologies including continuous glucose...
CONCEPTT: Continuous Glucose Monitoring in Women with Type 1 Diabetes in Pregnancy Trial
Denice S Feig, Elizabeth Asztalos, Rosa Corcoy, Alberto De Leiva, Lois Donovan, Moshe Hod, Lois Jovanovic, Erin Keely, Craig Kollman, Ruth McManus, Kellie Murphy, Katrina Ruedy, J Johanna Sanchez, George Tomlinson, Helen R Murphy, CONCEPTT Collaborative Group
Sep 29, 2016
BACKGROUND: Women with type 1 diabetes strive for optimal glycemic control before and during pregnancy to avoid adverse obstetric and perinatal outcomes. For most women, optimal glycemic control is challenging to achieve and...
Continuous glucose monitoring Diabetes mellitus type 1 Preconception Pregnancy Randomized controlled trial Adolescent Adult Birth Weight Blood Glucose Blood Glucose Self-Monitoring Diabetes mellitus Type 1 Female Glycated Hemoglobin Humans Hypoglycemia Hypoglycemic Agents Infant Newborn Insulin Monitoring Ambulatory Pregnancy Pregnancy Complications Pregnancy in Diabetics Research Design Young Adult
AiDAPT: automated insulin delivery amongst pregnant women with type 1 diabetes
Tara TM Lee, Corinne Collett, Mei-See Man, Matt Hammond, Lee Shepstone, Sara Hartnell, Eleanor Gurnell, Caroline Byrne, Eleanor M Scott, Robert S Lindsay, Damian Morris, Anna Brackenridge, Anna R Dover, Rebecca M Reynolds, Katharine F Hunt, David R McCance, Katharine Barnard-Kelly, David Rankin, Julia Lawton, Laura E Bocchino, Judy Sibayan, Craig Kollman, Malgorzata E Wilinska, Roman Hovorka, Helen R Murphy, AiDAPT Collaborative Group
Apr 06, 2022
BACKGROUND: Pregnant women with type 1 diabetes strive for tight glucose targets (3.5-7.8 mmol/L) to minimise the risks of obstetric and neonatal complications. Despite using diabetes technologies including continuous glucose...
Closed-loop insulin delivery in suboptimally controlled type 1 diabetes
Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Yue Ruan, Judy Sibayan, Craig Kollman, Peiyao Cheng, Roy W Beck, Carlo L Acerini, Mark L Evans, David B Dunger, Daniela Elleri, Fiona Campbell, Richard M Bergenstal, Amy Criego, Viral N Shah, Lalantha Leelarathna, Roman Hovorka, APCam11 Consortium
Sep 08, 2018
BACKGROUND: The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump...
Circulating extracellular vesicles during pregnancy in women with type 1 diabetes
Akram Abolbaghaei, Marc-André Langlois, Helen R Murphy, Denice S Feig, Dylan Burger, CONCEPTT Collaborative Group
Oct 08, 2021
BACKGROUND: Extracellular vesicles are membrane vesicles that are released into the extracellular environment and accumulate in the circulation in vascular disease. We aimed to quantify circulating extracellular vesicles in...
Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT)
Denice S Feig, Lois E Donovan, Rosa Corcoy, Kellie E Murphy, Stephanie A Amiel, Katharine F Hunt, Elizabeth Asztalos, Jon FR Barrett, J Johanna Sanchez, Alberto De Leiva, Moshe Hod, Lois Jovanovic, Erin Keely, Ruth McManus, Eileen K Hutton, Claire L Meek, Zoe A Stewart, Tim Wysocki, Robert O'Brien, Katrina Ruedy, Craig Kollman, George Tomlinson, Helen R Murphy, CONCEPTT Collaborative Group
Sep 09, 2019
BACKGROUND: Pregnant women with type 1 diabetes are a high-risk population who are recommended to strive for optimal glucose control, but neonatal outcomes attributed to maternal hyperglycaemia remain suboptimal. Our aim was to...
Gestational diabetes
Ponnusamy Saravanan, Diabetes in Pregnancy Working Group, Maternal Medicine Clinical Study Group, UK Royal College of Obstetricians and Gynaecologists
Apr 30, 2021
Gestational diabetes, the most common medical disorder in pregnancy, is defined as glucose intolerance resulting in hyperglycaemia that begins or is first diagnosed in pregnancy. Gestational diabetes is associated with increased...
Reducing occupational sitting time in adults with type 2 diabetes
AIM: Understanding barriers and facilitators for limiting occupational sitting and what impact it has on health on those with type 2 diabetes is essential for future trials and intervention development in primary healthcare...
Social Determinants of Health Are Associated with Markers of Renal Injury in Adolescents with Type 1 Diabetes.
Laura AM Cummings, Antoine Clarke, Etienne Sochett, Denis Daneman, David Z Cherney, Heather N Reich, James W Scholey, David B Dunger, Farid H Mahmud
Sep 21, 2018
OBJECTIVE: To examine the relationship between the social determinants of health and markers of early renal injury in adolescent patients with type 1 diabetes (T1D). STUDY DESIGN: Renal outcomes included estimated glomerular...
Exercise to preserve beta cell function in recent-onset type 1 diabetes mellitus (EXTOD) - a study protocol for a pilot randomized controlled trial
N. Lascar, A. Kennedy, N. Jackson, A. Daley, G. Dowswell, D. Thompson, K. Stokes, S. Greenfield, R. Holder, R. Andrews, P. Narendran
Jun 18, 2013
Background: Exercise has a beta cell preserving effect in patients with type 2 diabetes. This benefit of exercise has not been examined in type 1 diabetes. Significant beta cell function is present at the time of diagnosis of...
Exercise to preserve beta cell function in recent-onset type 1 diabetes mellitus (EXTOD) - a study protocol for a pilot randomized controlled trial
N. Lascar, A. Kennedy, N. Jackson, A. Daley, G. Dowswell, D. Thompson, K. Stokes, S. Greenfield, R. Holder, R. Andrews, P. Narendran
Jun 18, 2013
Background: Exercise has a beta cell preserving effect in patients with type 2 diabetes. This benefit of exercise has not been examined in type 1 diabetes. Significant beta cell function is present at the time of diagnosis of...
Effect of screening for type 2 diabetes on healthcare costs
Camilla Sortsø, Anastasija Komkova, Annelli Sandbæk, Simon J Griffin, Martha Emneus, Torsten Lauritzen, Rebecca K Simmons
May 16, 2018
AIMS/HYPOTHESIS: Trials have not demonstrated benefits to the population of screening for type 2 diabetes. However, there may be cost savings for those found to have diabetes. We therefore aimed to compare healthcare costs among...
Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis.
Lourdes Ortiz-Fernández, Francisco David Carmona, Raquel López-Mejías, Maria Francisca González-Escribano, Paul A Lyons, Ann W Morgan, Amr H Sawalha, Peter A Merkel, Kenneth GC Smith, Miguel A González-Gay, Javier Martín, UK GCA Consortium, Turkish Takayasu Study Group, Vasculitis Clinical Research Consortium, IgAV Study Group, AAV Study group Spanish GCA Study Group
Apr 18, 2018
OBJETIVE: Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we...
Autoantibodies outcomes research systemic sclerosis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Case-Control Studies Epigenesis Genetic Female Genetic Loci Genetic Predisposition to Disease Giant Cell Arteritis HLA-DQ Antigens HLA-DQ beta-Chains Humans Jumonji Domain-Containing Histone Demethylases Linkage Disequilibrium Male Phenotype Polymorphism Single Nucleotide Protein Array Analysis Systemic Vasculitis Takayasu arteritis
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