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Pendampingan Penguatan Karakter Pemuda “Muda Berkarakter, Hebat Berprestasi”
A Taufiq
Feb 04, 2025
Strengthening character for young people plays an important role, especially in improving a person's individuality by increasing the analysis of one's strengths and weaknesses in facing or preparing oneself for the world of work...
Published by: Akademi Kesejahteraan Sosial Ibu Kartini Semarang
Nearest Neighbor Decoding and Pilot-AidedChannel Estimation for Fading Channels
We study the information rates of noncoherent, stationary, Gaussian, and multiple-input multiple-output (MIMO) flat-fading channels that are achievable with nearest neighbor decoding and pilot-aided channel estimation. In...
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway.
The store-operated calcium entry (SOCE) pathway is an important route for generating cytosolic Ca2+ signals that regulate a diverse array of biological processes. Abnormal SOCE seem to underlie several diseases that notably...
Anilides Animals Biological Assay Calcium Calcium Signaling Cell Nucleus Drug Approval Drug Evaluation Preclinical HEK293 Cells HeLa Cells Humans Ion Channel Gating Ligands NFATC Transcription Factors ORAI1 Protein Protein Multimerization Protein Transport Rats Stromal Interaction Molecule 1 Thapsigargin Thiadiazoles United States United States Food and Drug Administration User-Computer Interface
Nearest Neighbor Decoding and Pilot-AidedChannel Estimation for Fading Channels
We study the information rates of noncoherent, stationary, Gaussian, and multiple-input multiple-output (MIMO) flat-fading channels that are achievable with nearest neighbor decoding and pilot-aided channel estimation. In...
A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.
Zhu-Hong Li, Thayer P King, Lawrence Ayong, Beejan Asady, Xinjiang Cai, Taufiq Rahman, Stephen A Vella, Isabelle Coppens, Sandip Patel, Silvia NJ Moreno
Nov 25, 2021
Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca2+-dependent events. Little is known about TPCs in unicellular organisms despite...
Identification and Validation of Carbonic Anhydrase II as the First Target of the Anti-Inflammatory Drug Actarit.
Background and purpose: Identifying the macromolecular targets of drug molecules is a fundamental aspect of drug discovery and pharmacology. Several drugs remain without known targets (orphan) despite large-scale in silico and...
Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like Protease
The ongoing coronavirus pandemic has been a burden on the worldwide population, with mass fatalities and devastating socioeconomic consequences. It has particularly drawn attention to the lack of approved small-molecule drugs to...
A plastid two-pore channel essential for inter-organelle communication and growth of Toxoplasma gondii.
Zhu-Hong Li, Thayer P King, Lawrence Ayong, Beejan Asady, Xinjiang Cai, Taufiq Rahman, Stephen A Vella, Isabelle Coppens, Sandip Patel, Silvia N J Moreno
Nov 05, 2021
Two-pore channels (TPCs) are a ubiquitous family of cation channels that localize to acidic organelles in animals and plants to regulate numerous Ca2+-dependent events. Little is known about TPCs in unicellular...
Published by: Nature Communications
Loss sensitive investors and positively biased analysts in Hong Kong stock market
Taufiq Choudhry, Gishan Dissanaike, Ranadeva Jayasekera, Woo-Young Kang, Matthias Nnadi
Sep 22, 2021
Abstract: The Hong Kong stock market is known to be highly volatile. Professional investors have a strong demand for timely information because of the infrequent nature of Hong Kong analysts’ interim reports (Cheng et al....
Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease
The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over...
Identification and Validation of Carbonic Anhydrase II as the First Target of the Anti-Inflammatory Drug Actarit
Background and purpose: Identifying the macromolecular targets of drug molecules is a fundamental aspect of drug discovery and pharmacology. Several drugs remain without known targets (orphan) despite large-scale in silico and...
Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in Pseudomonas aeruginosa.
Yassmin Abdelhamid, Meng Wang, Susannah L Parkhill, Paul Brear, Xavier Chee, Taufiq Rahman, Martin Welch
Jan 28, 2022
Pseudomonas aeruginosa (PA) depends on the Entner-Doudoroff pathway (EDP) for glycolysis. The main enzymatic regulator in the lower half of the EDP is pyruvate kinase. PA contains genes that encode two isoforms of pyruvate...
Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like Protease.
The ongoing coronavirus pandemic has been a burden on the worldwide population, with mass fatalities and devastating socioeconomic consequences. It has particularly drawn attention to the lack of approved small-molecule drugs to...
covid-19 PLpro SARS coronavirus 2 analogues docking Drug Discovery In silico papain-like protease Scaffold hopping Virtual screening Antiviral Agents covid-19 Coronavirus 3C Proteases Crystallography X-Ray Cysteine Proteinase Inhibitors Drug Evaluation Preclinical Humans Molecular Docking Simulation SARS-CoV-2 COVID-19 Drug Treatment
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Novel Small-Molecule Scaffolds as Candidates against the SARS Coronavirus 2 Main Protease
The ongoing pandemic caused by the novel coronavirus has been the greatest global health crisis since the Spanish flu pandemic of 1918. Thus far, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in over...
Electrophysiology of Endolysosomal Two-Pore Channels
Sandip Patel, Yu Yuan, Cheng-Chang Chen, Dawid Jaślan, Gihan Gunaratne, Christian Grimm, Taufiq Rahman, Jonathan S Marchant
Aug 04, 2022
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels. Direct macroscopic recordings of...
Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in Pseudomonas aeruginosa.
Yassmin Abdelhamid, Meng Wang, Susannah L Parkhill, Paul Brear, Xavier Chee, Md Taufiq Rahman, Martin Welch
Dec 15, 2021
Pseudomonas aeruginosa (PA) depends on the Entner-Doudoroff pathway (EDP) for glycolysis. The main enzymatic regulator in the lower half of the EDP is pyruvate kinase. PA contains genes that encode two isoforms of pyruvate...
Exploration of inositol 1,4,5-trisphosphate (IP3) regulated dynamics of N-terminal domain of IP3 receptor reveals early phase molecular events during receptor activation.
Inositol 1, 4, 5-trisphosphate (IP3) binding at the N-terminus (NT) of IP3 receptor (IP3R) allosterically triggers the opening of a Ca2+-conducting pore located ~100 Å away from the IP3-binding core (IBC). However, the precise...
Electrophysiology of Endolysosomal Two-Pore Channels
Sandip Patel, Yu Yuan, Cheng-Chang Chen, Dawid Jaślan, Gihan Gunaratne, Christian Grimm, Taufiq Rahman, Jonathan S Marchant
Sep 11, 2022
Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically relevant proteins that reside on endolysosomal vesicles. Here, we review the electrophysiology of these channels. Direct macroscopic recordings of...
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
A Model of Cloud Forensic Application With Assurance of Cloud Log
The key concepts of digital forensic investigation in cloud computing are examination and investigation. Cybercriminals target cloud-based web applications due to presence of vulnerabilities. Forensic investigation is a complex...
Published by: IGI Global Scientific Publishing
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