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Results: 239
Neutrophil GM-CSF receptor dynamics in acute lung injury.
Silvia De Alessandris, G John Ferguson, Alison J Dodd, Jatinder K Juss, Abhinandan Devaprasad, Siân Piper, Owen Wyatt, Helen Killick, Dominic J Corkill, E Suzanne Cohen, Aridaman Pandit, Timothy RDJ Radstake, Rosalind Simmonds, Alison M Condliffe, Matthew A Sleeman, Andrew S Cowburn, Donna K Finch, Edwin R Chilvers
May 07, 2019
GM-CSF is important in regulating acute, persistent neutrophilic inflammation in certain settings, including lung injury. Ligand binding induces rapid internalization of the GM-CSF receptor (GM-CSFRα) complex, a process...
LPS Alveolar Apoptosis Inflammation signaling Acute Lung Injury Adult Animals Cell Line Tumor Cytokine Receptor Common beta Subunit Disease Models Animal Female Gene Expression Regulation Humans Lipopolysaccharides Male Mice Mice Inbred BALB C Mice Transgenic Neutrophils Pulmonary Alveoli Receptors Granulocyte-Macrophage Colony-Stimulating Factor Time Factors
GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation.
Tomas Castro-Dopico, Aaron Fleming, Thomas W Dennison, John R Ferdinand, Katherine Harcourt, Benjamin J Stewart, Zaeem Cader, Zewen K Tuong, Chenzhi Jing, Laurence SC Lok, Rebeccah J Mathews, Anaïs Portet, Arthur Kaser, Simon Clare, Menna R Clatworthy
Jun 16, 2020
Macrophages play a central role in intestinal immunity, but inappropriate macrophage activation is associated with inflammatory bowel disease (IBD). Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as...
GM-CSF anti-microbial defense Crosstalk inflammatory bowel disease innate lymphoid cells MACROPHAGES Wound Healing Animals Cell Polarity Citrobacter rodentium Colitis Enterobacteriaceae Infections Granulocyte-Macrophage Colony-Stimulating Factor Humans Immunity Innate Inflammation Intestines Lymphocytes Macrophage Activation MACROPHAGES Mice Inbred C57BL Phenotype Wound Healing
Arrhythmia Detection Using Deep Belief Network Extracted Features From ECG Signals
Mahendra Gourisaria, Harshvardhan GM, Rakshit Agrawal, Sudhansu Patra, Siddharth Rautaray, Manjusha Pandey
Nov 01, 2021
Arrhythmia is a disorder of the heart caused by the erratic nature of heartbeats occurring due to conduction failures of the electrical signals in the cardiac muscle. In recent years, research galore has been done towards...
Published by: IGI Global Scientific Publishing
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF.
Jan Felix, Eaazhisai Kandiah, Steven De Munck, Yehudi Bloch, Gydo CP van Zundert, Kris Pauwels, Ann Dansercoer, Katka Novanska, Randy J Read, Alexandre MJJ Bonvin, Bjorn Vergauwen, Kenneth Verstraete, Irina Gutsche, Savvas N Savvides
Jul 06, 2020
Subversion of the host immune system by viruses is often mediated by molecular decoys that sequester host proteins pivotal to mounting effective immune responses. The widespread mammalian pathogen parapox Orf virus deploys GIF...
Bandwidth Estimation and Optimized Bitrate Selection for Dynamic Adaptive Streaming Over HTTP Using RSI-GM and ISSO
Dynamic Adaptive Streaming over HTTP (DASH) is an emerging solution that aims to standardize existing proprietary streaming systems. DASH specification defines the media presentation description (MPD), which describes a list of...
Computer Vision & Image Processing Computer Science and Information Technology Computer Vision and Machine Perception
Published by: IGI Global Scientific Publishing
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).
Jatin Patel, Damon Bass, Albertus Beishuizen, Xavier Bocca Ruiz, Hatem Boughanmi, Anthony Cahn, Hugo Colombo, Gerard J Criner, Katherine Davy, Javier de-Miguel-Díez, Pablo A Doreski, Sofia Fernandes, Bruno François, Anubha Gupta, Kate Hanrott, Timothy Hatlen, Dave Inman, John D Isaacs, Emily Jarvis, Natalia Kostina, Tatiana Kropotina, Jean-Claude Lacherade, Divya Lakshminarayanan, Pedro Martinez-Ayala, Charlene McEvoy, Ferhat Meziani, Mehran Monchi, Sumanta Mukherjee, Rosana Muñoz-Bermúdez, Jessica Neisen, Ciara O'Shea, Gaëtan Plantefeve, Lorrie Schifano, Lee E Schwab, Zainab Shahid, Michinori Shirano, Julia E Smith, Eduardo Sprinz, Charlotte Summers, Nicolas Terzi, Mark A Tidswell, Yuliya Trefilova, Russell Williamson, Duncan Wyncoll, Mark Layton
Nov 16, 2022
BACKGROUND: Granulocyte-macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19. METHODS: In this randomised, sequential, multicentre...
Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W. Ritchie, Li Su, Graciela Muniz-Terrera, John T. O’Brien
Apr 24, 2021
Abstract: Background: Structural brain changes associated with Alzheimer’s disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be...
Improving Shipping Efficiency Industry-Led Consortium Blockchain Smart Contact
COVID-19 has recently affected global trade flows, and the primary reason is that shipping failed to adapt rapidly to meet the need for on-time delivery. Given blockchain's “revolutionary” potential, this paper aims to...
Published by: IGI Global Scientific Publishing
Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.
Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W Ritchie, Li Su, Graciela Muniz-Terrera, John T O'Brien
Dec 23, 2020
BACKGROUND: Structural brain changes associated with Alzheimer's disease (AD) can occur decades before the onset of symptoms. The Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) score has been suggested to be associated...
Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation
Puja Mehta, Joanna C Porter, Jessica J Manson, John D Isaacs, Peter JM Openshaw, Iain B McInnes, Charlotte Summers, Rachel C Chambers
Jun 11, 2020
The COVID-19 pandemic is a global public health crisis, with considerable mortality and morbidity exerting pressure on health-care resources, including critical care. An excessive host inflammatory response in a subgroup of...
Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils.
Andrew S Cowburn, Charlotte Summers, Benjamin J Dunmore, Neda Farahi, Richard P Hayhoe, Cristin G Print, Simon J Cook, Edwin R Chilvers
Jun 19, 2018
Neutrophil apoptosis is essential for the resolution of inflammation but is delayed by several inflammatory mediators. In such terminally differentiated cells it has been uncertain whether these agents can inhibit apoptosis...
Apoptosis Apoptosis Regulatory Proteins Bcl-2-Like Protein 11 Caspase 9 Cell Survival Gene Expression Regulation Granulocyte Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Humans Inflammation Membrane Proteins Microscopy Confocal Models Biological Neutrophils Phenotype Pneumonia Proto-Oncogene Proteins Tumor Necrosis Factor-alpha
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells
Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett
Sep 30, 2020
Abstract: Vascular smooth muscle cells (VSMCs) are the main structural cell of blood vessels, and VSMC apoptosis occurs in vascular disease, after injury, and in vessel remodeling during development. Although VSMC apoptosis is...
Gray matter changes related to microglial activation in Alzheimer's disease.
Nicolas Nicastro, Maura Malpetti, Elijah Mak, Guy B Williams, W Richard Bevan-Jones, Stephen F Carter, Luca Passamonti, Tim D Fryer, Young T Hong, Franklin I Aigbirhio, James B Rowe, John T O'Brien
Jun 12, 2020
Neuroinflammation is increasingly recognized as playing a key pathogenetic role in Alzheimer's disease (AD). We examined the relationship between in vivo neuroinflammation and gray matter (GM) changes. Twenty-eight subjects with...
Education and Income Show Heterogeneous Relationships to Lifespan Brain and Cognitive Differences Across European and US Cohorts.
Kristine B Walhovd, Anders M Fjell, Yunpeng Wang, Inge K Amlien, Athanasia M Mowinckel, Ulman Lindenberger, Sandra Düzel, David Bartrés-Faz, Klaus P Ebmeier, Christian A Drevon, William FC Baaré, Paolo Ghisletta, Louise Baruël Johansen, Rogier A Kievit, Richard N Henson, Kathrine Skak Madsen, Lars Nyberg, Jennifer R Harris, Cristina Solé-Padullés, Sara Pudas, Øystein Sørensen, René Westerhausen, Enikő Zsoldos, Laura Nawijn, Torkild Hovde Lyngstad, Sana Suri, Brenda Penninx, Ole J Rogeberg, Andreas M Brandmaier
Sep 20, 2021
Higher socio-economic status (SES) has been proposed to have facilitating and protective effects on brain and cognition. We ask whether relationships between SES, brain volumes and cognitive ability differ across cohorts, by age...
Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells
Dimitra Aravani, Kirsty Foote, Nichola Figg, Alison Finigan, Anna Uryga, Murray Clarke, Martin Bennett
Jul 07, 2021
Abstract: Vascular smooth muscle cells (VSMCs) are the main structural cell of blood vessels, and VSMC apoptosis occurs in vascular disease, after injury, and in vessel remodeling during development. Although VSMC apoptosis is...
Amalgamated Evolutionary Approach for Optimized Routing in Time Varying Ultra Dense Heterogeneous Networks
Kandarpa Sarma, Debashis Misra, Pradyut Goswami, Subhrajyoti Bordoloi, Utpal Bhattacharjee
Jan 01, 2022
Routing mechanisms in Ultra-Dense Network (UDNs) are expected to be flexible, scalable, and robust in nature and the establishment of the shortest path between the source and destination pairs will always be a critical...
Published by: IGI Global Scientific Publishing
Granulocytes, macrophages, and dendritic cells arise from a common major histocompatibility complex class II-negative progenitor in mouse bone marrow
The developmental origin of dendritic cells, a specialized system of major histocompatibility complex (MHC) class II-rich antigen-presenting cells for T-cell immunity and tolerance, is not well characterized....
bone marrow cell cell granule cellular immunity dendritic cell granulocyte macrophage mixed lymphocyte reaction stem cell
Published by: Rockefeller University
Diffusion MRI approaches for investigating microstructural complexity in a rat model of traumatic brain injury.
Karthik Chary, Eppu Manninen, Jade Claessens, Alonso Ramirez-Manzanares, Olli Gröhn, Alejandra Sierra
Feb 09, 2023
Our study explores the potential of conventional and advanced diffusion MRI techniques including diffusion tensor imaging (DTI), and single-shell 3-tissue constrained spherical deconvolution (SS3T-CSD) to investigate complex...
DrugClust
Background: Identification of underlying mechanisms behind drugs side effects is of extreme interest and
importance in drugs discovery today. Therefore machine learning methodology, linking such different
multi features aspects...
Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage.
Audrey Low, Elijah Mak, James D Stefaniak, Maura Malpetti, Nicolas Nicastro, George Savulich, Leonidas Chouliaras, Hugh S Markus, James B Rowe, John T O'Brien
May 09, 2020
The peak width of skeletonized mean diffusivity (PSMD) has been proposed as a fully automated imaging marker of relevance to cerebral small vessel disease (SVD). We assessed PSMD in relation to conventional SVD markers, global...
Published by: Frontiers in neuroscience
Patterns of gray matter atrophy in genetic frontotemporal dementia
David M Cash, Martina Bocchetta, David L Thomas, Katrina M Dick, John C van Swieten, Barbara Borroni, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, James Rowe, Caroline Graff, Fabrizio Tagliavini, Giovanni B Frisoni, Robert Laforce, Elizabeth Finger, Alexandre de Mendonça, Sandro Sorbi, Martin N Rossor, Sebastien Ourselin, Jonathan D Rohrer, GENFI, Genetic FTD Initiative
Feb 05, 2018
Frontotemporal dementia (FTD) is a highly heritable condition with multiple genetic causes. In this study, similarities and differences of gray matter (GM) atrophy patterns were assessed among 3 common forms of genetic FTD...
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