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Effects of noise on integration of acoustic and electric hearing within and across ears
In bimodal listening, cochlear implant (CI) users combine electric hearing (EH) in one ear and acoustic hearing (AH) in the other ear. In electric-acoustic stimulation (EAS), CI users combine EH and AH in the same ear. In quiet...
Rising from the depths network
The Rising from the Depths (RftD) network aims to identify the ways in which Marine Cultural Heritage (MCH) can contribute to the sustainable development of coastal communities in Kenya, Tanzania, Mozambique and...
J Henderson, C Breen, L Esteves, A La Chimia, P Lane, S Macamo, G Marvin, S Wynne-Jones
Jun 24, 2021
Insights into the Control of Drug Release from Complex Immediate Release Formulations
Runqiao Dong, James C. DiNunzio, Brian P. Regler, Walter Wasylaschuk, Adam Socia, J. Axel Zeitler
Jun 25, 2021
The kinetics of water transport into tablets, and how it can be controlled by the formulation as well as the tablet microstructure, are of central importance in order to design and control the dissolution and drug release...
Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas.
N Burrows, J Resch, RL Cowen, R von Wasielewski, C Hoang-Vu, CM West, KJ Williams, G Brabant
May 26, 2021
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is upregulated by hypoxia and oncogenic signalling in many solid tumours. Its regulation and function in thyroid carcinomas are unknown. We evaluated the regulation of HIF-1 alpha...
Adenocarcinoma Follicular Anaerobiosis Antigens Neoplasm Carbonic Anhydrase IX Carbonic Anhydrases Carcinoma Carcinoma Papillary Cell Hypoxia Cell Line Tumor Chromones cobalt Gene Expression Regulation Neoplastic Glucose Transporter Type 1 Humans Hypoxia-Inducible Factor 1 alpha Subunit Morpholines Neoplasm Proteins PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases Phosphoinositide-3 Kinase Inhibitors Proto-Oncogene Proteins B-raf RNA Interference RNA Small Interfering Signal Transduction Thyroid Neoplasms
Aspirin and cancer survival
Peter C Elwood, Gareth Morgan, Christine Delon, Majd Protty, Julieta Galante, Janet Pickering, John Watkins, Alison Weightman, Delyth Morris
Aug 02, 2021
BACKGROUND: Despite the accumulation of research papers on aspirin and cancer, there is doubt as to whether or not aspirin is an acceptable and effective adjunct treatment of cancer. The results of several randomised trials are...
Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments.
Stacey J Scott, Xiaodun Li, Sriganesh Jammula, Ginny Devonshire, Catherine Lindon, Rebecca C Fitzgerald, Pier Paolo D'Avino
Jan 29, 2021
Polyploidy is present in many cancer types and is increasingly recognized as an important factor in promoting chromosomal instability, genome evolution, and heterogeneity in cancer cells. However, the mechanisms that trigger...
15% reduction in AC loss of a 3-phase 1 MVA HTS transformer by exploiting asymmetric conductor critical current
An asymmetric dependence of the critical current on the direction of an applied magnetic field in HTS coated conductors has a non-trivial influence on the AC loss of coil windings. We report the modelled influence of real...
Implications of the variation in biological 18 O natural abundance in body water to inform use of Bayesian methods for modelling total energy expenditure when using doubly labelled water.
RATIONALE: Variation in 18 O natural abundance can lead to errors in the calculation of total energy expenditure (TEE) when using the doubly labelled water (DLW) method. The use of Bayesian statistics allows a distribution to be...
Estimating the Population Benefits of Blood Pressure Lowering
Hannah Higgins, Amy M Mason, Susanna C Larsson, Dipender Gill, Claudia Langenberg, Stephen Burgess
Sep 20, 2021
Background The causal relevance of elevated blood pressure for several cardiovascular diseases (CVDs) is uncertain, as is the population impact of blood pressure lowering. This study systematically assesses evidence of causality...
Mendelian randomization cardiovascular disease Genetic epidemiology high blood pressure Hypertension Adult Aged Biological Specimen Banks blood pressure Cardiovascular Diseases Causality Genome-Wide Association Study Humans Hypertension Mendelian Randomization Analysis Middle Aged Polymorphism Single Nucleotide Risk Factors United Kingdom
A downsized and optimised intracellular library-derived peptide prevents alpha-synuclein primary nucleation and toxicity without impacting upon lipid binding
Misfolding and aggregation of alpha-synuclein (αS) within dopaminergic neurons is a key factor in the development and progression of a group of age-related neurodegenerative diseases, termed synucleinopathies, that include...
A downsized and optimised intracellular library-derived peptide prevents alpha-synuclein primary nucleation and toxicity without impacting upon lipid binding
Misfolding and aggregation of alpha-synuclein (αS) within dopaminergic neurons is a key factor in the development and progression of a group of age-related neurodegenerative diseases, termed synucleinopathies, that include...
Anionic lipid vesicles have differential effects on the aggregation of early onset-associated α-synuclein missense mutants
α-synuclein (αS) is the key component of synucleinopathies such as Parkinson's disease (PD), dementia with Lewy bodies, and multiple system atrophy. αS was first linked to PD through the identification of point mutations in...
Ursinus College Alumni Journal, May 1952
J. Harold Brownback, Muriel B. Pancoast, Calvin D. Yost, Louis A. Krug, Paul Levengood, Raymond V. Gurzynski, Norman E. McClure, Marian H. Reifsnyder, Harvey R. Vanderslice
Jan 01, 0001
President's page Dr. Paisley honored as layman-of-the-year Dr. Creese to deliver commencement address New students enroll for second semester Dr. Lachman presents bust of Washington Anne Hughes speaks at Ursinus Color Day ...
Ursinus College Collegeville Pennsylvania alumni Deaths Marriages Harry E. Paisley James Creese Charles Lachman Jeanne Careless Anne Hughes Color Day Jack Webb Gladys Hoagland Garlock Samuel S. Laucks David I. Jacobs P. Wesley Bare Eveline Omwake Bill Daniels wrestling baseball Basketball badminton track team Swimming tennis placement services Charles H. Brown Ira J. Hain Higher Education Social History United States History
Published by: Ursinus College
The Lantern Vol. 3, No. 1, December 1934
John H. Brown, Jr., Wilhelmina Meinhardt, Dorothy Witmer, Eugene Shelley, Ruth I. Hamma, Ione B. Hausmann, Regina S. Romberger, Elizabeth McBride, Dorothy E. Horne, Kathleen Black, Paul Williams
Jan 01, 0001
Magic Words The Old Trappe Church The "Light of Life" Edwin Markham: Impressions Increment (A Christmas Thought) Our Christmas What Price Forgetting? Autumn The Old Parson Zacharias Ursinus Inspiration A...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Trappe Augustus Lutheran Church Zacharias Baer Zacharias Ursinus Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
Extensive migration of young neurons into the infant human frontal lobe.
Mercedes F Paredes, David James, Sara Gil-Perotin, Hosung Kim, Jennifer A Cotter, Carissa Ng, Kadellyn Sandoval, David H Rowitch, Duan Xu, Patrick S McQuillen, Jose-Manuel Garcia-Verdugo, Eric J Huang, Arturo Alvarez-Buylla
Nov 21, 2017
The first few months after birth, when a child begins to interact with the environment, are critical to human brain development. The human frontal lobe is important for social behavior and executive function; it has increased in...
Postnatal growth in preterm infants and later health outcomes
Kenneth Ong, Kathy Kennedy, Eurídice Castañeda-Gutiérrez, Stewart Forsyth, Keith M Godfrey, Berthold Koletzko, Marie E Latulippe, Susan Ozanne, Ricardo Rueda, Marieke H Schoemaker, Eline M van der Beek, Stef van Buuren, Mary Fewtrell
Nov 04, 2015
In preterm infants, poor postnatal growth is associated with adverse neurocognitive outcomes; conversely, rapid postnatal growth is supposedly harmful for future development of metabolic diseases. CONCLUSION: In this systematic...
Iron and hepcidin as risk factors in atherosclerosis
Tessel E Galesloot, Luc L Janss, Stephen Burgess, Lambertus ALM Kiemeney, Martin den Heijer, Jacqueline de Graaf, Suzanne Holewijn, Beben Benyamin, John B Whitfield, Dorine W Swinkels, Sita H Vermeulen
Sep 29, 2016
BACKGROUND: Previous reports suggested a role for iron and hepcidin in atherosclerosis. Here, we evaluated the causality of these associations from a genetic perspective via (i) a Mendelian randomization (MR) approach, (ii)...
Association of tamoxifen use and reduced risk of contralateral breast cancer for BRCA1 and BRCA2 mutation carriers
KA Phillips, RL Milne, MA Rookus, D Goldgar, M Friedlander, SA McLachlan, S Buys, AC Antoniou, K Birch, MB Terry, DF Easton, P Weideman, M Daly, N Andrieu, EM John, MJ Hooning, IL Andrulis, T Caldes, H Olsson, JL Hopper
Apr 12, 2012
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children.
Courtney E French, Isabelle Delon, Helen Dolling, Alba Sanchis-Juan, Olga Shamardina, Karyn Mégy, Stephen Abbs, Topun Austin, Sarah Bowdin, Ricardo G Branco, Helen Firth, NIHR BioResource—Rare Disease, Next Generation Children Project, David H Rowitch, F Lucy Raymond
May 07, 2019
PURPOSE: With growing evidence that rare single gene disorders present in the neonatal period, there is a need for rapid, systematic, and comprehensive genomic diagnoses in ICUs to assist acute and long-term clinical decisions....
Critically ill children Genetics Genomics NICU PICU whole genome sequencing Adolescent Child Child Preschool Cohort Studies Critical Illness England Female Genetic background Genetic Diseases Inborn Humans Infant Infant Newborn Intensive Care Units Neonatal Intensive Care Units Pediatric Male Prospective Studies State Medicine whole genome sequencing Young Adult
Familial risk of autism alters subcortical and cerebellar brain anatomy in infants and predicts the emergence of repetitive behaviors in early childhood.
Inês Pote, Siying Wang, Vaheshta Sethna, Anna Blasi, Eileen Daly, Maria Kuklisova-Murgasova, Sarah Lloyd-Fox, Evelyne Mercure, Paula Busuulwa, Vladimira Stoencheva, Tony Charman, Steven Cr Williams, Mark H Johnson, Declan GM Murphy, Grainne M McAlonan, BASIS Team
May 09, 2019
Autism spectrum disorder (ASD) is a common neurodevelopmental condition, and infant siblings of children with ASD are at a higher risk of developing autistic traits or an ASD diagnosis, when compared to those with typically...
Autism spectrum disorder cerebellum familial risk infants magnetic resonance imaging-structural mother-infant interaction subcortex Autism spectrum disorder Brain Female Genetic Predisposition to Disease Humans Infant Magnetic Resonance Imaging Male Organ Size Prospective Studies risk Siblings Stereotyped Behavior
HIV-1 Transmission Clustering and Phylodynamics Highlight the Important Role of Young Men Who Have Sex with Men.
Ann M Dennis, Erik Volz, AS Md Simon DW Frost, Mukarram Hossain, Art FY Poon, Peter F Rebeiro, Sten H Vermund, Timothy R Sterling, Marcia L Kalish
Jun 05, 2019
More persons living with HIV reside in the Southern United States than in any other region, yet little is known about HIV molecular epidemiology in the South. We used cluster and phylodynamic analyses to evaluate HIV...
HIV-1 Southeastern United States men who have sex with men molecular epidemiology Phylogeny transmission Adolescent Adult Age Factors Cluster Analysis Cross-Sectional Studies Female Genotype HIV Infections HIV-1 Homosexuality male Humans Male Middle Aged molecular epidemiology Phylogeny RNA Viral Retrospective Studies Risk Factors Sequence Analysis DNA Tennessee Young Adult pol Gene Products Human Immunodeficiency Virus
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.
Sonia Baig, Muhammad Shabeer, Ehsan Parvaresh Rizi, Madhur Agarwal, Michelle H Lee, Delicia Shu Qin Ooi, Chelsea Chia, Nweni Aung, Geelyn Ng, Yvonne Teo, Vanna Chhay, Faidon Magkos, Antonio Vidal-Puig, Raymond CS Seet, Sue-Anne Toh
Oct 08, 2020
INTRODUCTION AND OBJECTIVE: Heredity of type 2 diabetes mellitus (T2DM) is associated with greater risk for developing T2DM. Thus, individuals who have a first-degree relative with T2DM (FDRT) provide a natural model to study...
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