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Results: 12001
Ionized and Molecular Gas Kinematics in a z = 1.4 Star-forming Galaxy
H. Übler, R. Genzel, L. J. Tacconi, N. M. Förster Schreiber, R. Neri, A. Contursi, S. Belli, E. J. Nelson, P. Lang, T. T. Shimizu, R. Davies, R. Herrera-Camus, D. Lutz, P. M. Plewa, S. H. Price, K. Schuster, A. Sternberg, K. Tadaki, E. Wisnioski, S. Wuyts
Feb 16, 2018
We present deep observations of a z = 1.4 massive, star-forming galaxy (SFG) in molecular and ionized gas at comparable spatial resolution (CO 3-2, NOrthern Extended Millimeter Array (NOEMA); Hα, Large Binocular Telescope...
A novel terpene synthase controls differences in anti-aphrodisiac pheromone production between closely related Heliconius butterflies
Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.
Monica C Pillon, Meredith N Frazier, Lucas B Dillard, Jason G Williams, Seda Kocaman, Juno M Krahn, Lalith Perera, Cassandra K Hayne, Jacob Gordon, Zachary D Stewart, Mack Sobhany, Leesa J Deterding, Allen L Hsu, Venkata P Dandey, Mario J Borgnia, Robin E Stanley
Jan 27, 2021
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric...
Ageing compromises mouse thymus function and remodels epithelial cell differentiation
Altered Cardiovascular Defense to Hypotensive Stress in the Chronically Hypoxic Fetus.
A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention
Natalia del Campo, Tim D Fryer, Young T Hong, Rob Smith, Laurent Brichard, Julio Acosta-Cabronero, Samuel R Chamberlain, Roger Tait, David Izquierdo, Ralf Regenthal, Jonathan Dowson, John Suckling, Jean-Claude Baron, Franklin I Aigbirhio, Trevor W Robbins, Barbara J Sahakian, Ulrich Müller
Aug 19, 2020
Through the combined use of (18)F-fallypride positron emission tomography and magnetic resonance imaging this study examined the neural mechanisms underlying the attentional deficits associated with attention...
18F-fallypride PET Dopamine methylphenidate sustained attention Adult Attention Deficit Disorder with Hyperactivity Benzamides Corpus Striatum Cross-Over Studies Dopamine Uptake Inhibitors Double-Blind Method Fluorodeoxyglucose F18 Humans Magnetic Resonance Imaging Male Mesencephalon methylphenidate Multimodal Imaging Positron-Emission Tomography Psychiatric Status Rating Scales Radiopharmaceuticals Young Adult
Published by: Brain
Genomic footprints of activated telomere maintenance mechanisms in cancer.
Lina Sieverling, Chen Hong, Sandra D Koser, Philip Ginsbach, Kortine Kleinheinz, Barbara Hutter, Delia M Braun, Isidro Cortés-Ciriano, Ruibin Xi, Rolf Kabbe, Peter J Park, Roland Eils, Matthias Schlesner, PCAWG-Structural Variation Working Group, Benedikt Brors, Karsten Rippe, David TW Jones, Lars Feuerbach, PCAWG Consortium
Mar 05, 2021
Cancers require telomere maintenance mechanisms for unlimited replicative potential. They achieve this through TERT activation or alternative telomere lengthening associated with ATRX or DAXX loss. Here, as part of the ICGC/TCGA...
Species specificity and intraspecific variation in the chemical profiles of Heliconius butterflies across a large geographic range.
Kathy Darragh, Gabriela Montejo-Kovacevich, Krzysztof M Kozak, Colin R Morrison, Clarisse ME Figueiredo, Jonathan S Ready, Camilo Salazar, Mauricio Linares, Kelsey JRP Byers, Richard M Merrill, W Owen McMillan, Stefan Schulz, Chris D Jiggins
Feb 03, 2020
In many animals, mate choice is important for the maintenance of reproductive isolation between species. Traits important for mate choice and behavioral isolation are predicted to be under strong stabilizing selection within...
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies.
ANCA-Associated Glomerulonephritis
Arda Göçeroğlu, Annelies E Berden, Marta Fiocco, Oliver Flossmann, Kerstin W Westman, Franco Ferrario, Gill Gaskin, Charles D Pusey, E Christiaan Hagen, Laure-Hélène Noël, Niels Rasmussen, Rüdiger Waldherr, Michael Walsh, Jan A Bruijn, David RW Jayne, Ingeborg M Bajema, European Vasculitis Society (EUVAS)
Feb 24, 2020
Relapse in ANCA-associated vasculitis (AAV) has been studied previously, but there are few studies on renal relapse in particular. Identifying patients at high risk of renal relapse may aid in optimizing clinical management. We...
Aged Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Antibodies Antineutrophil Cytoplasmic Chronic Disease Europe Female Follow-Up Studies Glomerular Filtration Rate glomerulonephritis Humans Incidence Kidney Kidney Failure Chronic Male Middle Aged Proportional Hazards Models Recurrence Regression Analysis Risk Factors Treatment Outcome
Connectomics Analysis Reveals First-, Second-, and Third-Order Thermosensory and Hygrosensory Neurons in the Adult Drosophila Brain.
Elizabeth C Marin, Laurin Büld, Maria Theiss, Tatevik Sarkissian, Ruairí JV Roberts, Robert Turnbull, Imaan FM Tamimi, Markus W Pleijzier, Willem J Laursen, Nik Drummond, Philipp Schlegel, Alexander S Bates, Feng Li, Matthias Landgraf, Marta Costa, Davi D Bock, Paul A Garrity, Gregory SXE Jefferis
Jun 10, 2020
Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.
Matthew Baxter, Maria Voronkov, Toryn Poolman, Gina Galli, Christian Pinali, Laurence Goosey, Abigail Knight, Karolina Krakowiak, Robert Maidstone, Mudassar Iqbal, Min Zi, Sukhpal Prehar, Elizabeth J Cartwright, Julie Gibbs, Laura C Matthews, Antony D Adamson, Neil E Humphreys, Pedro Rebelo-Guiomar, Michal Minczuk, David A Bechtold, Andrew Loudon, David Ray
Mar 16, 2020
Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly...
Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.
A multi-national qualitative research study exploring the patient experience of Raynaud's phenomenon in systemic sclerosis
John D Pauling, Robyn T Domsic, Lesley A Saketkoo, Celia Almeida, Jane Withey, Hilary Jay, Tracy M Frech, Francesca Ingegnoli, Emma Dures, Joanna Robson, Neil J McHugh, Ariane L Herrick, Marco Matucci-Cerinic, Dinesh Khanna, Sarah Hewlett
Sep 30, 2018
OBJECTIVES: Raynaud's phenomenon (RP) is the commonest manifestation of systemic sclerosis (SSc). RP is an episodic phenomenon, not easily assessed in the clinic, leading to reliance on self-report. A thorough understanding...
In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.
Elijah Mak, Richard AI Bethlehem, Rafael Romero-Garcia, Simon Cervenka, Timothy Rittman, Silvy Gabel, Ajenthan Surendranathan, Richard W Bevan-Jones, Luca Passamonti, Patricia Vázquez Rodríguez, Li Su, Robert Arnold, Guy B Williams, Young T Hong, Tim D Fryer, Franklin I Aigbirhio, James B Rowe, John T O'Brien
Oct 03, 2018
Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.
Jessica L Forbester, Emily A Lees, David Goulding, Sally Forrest, Amy Yeung, Anneliese Speak, Simon Clare, Eve L Coomber, Subhankar Mukhopadhyay, Judith Kraiczy, Fernanda Schreiber, Trevor D Lawley, Robert EW Hancock, Holm H Uhlig, Matthias Zilbauer, Fiona Powrie, Gordon Dougan
Feb 15, 2019
Intestinal epithelial cells (IECs) play a key role in regulating immune responses and controlling infection. However, the direct role of IECs in restricting pathogens remains incompletely understood. Here, we provide evidence...
NF-κB-Dependent Lymphoid Enhancer Co-option Promotes Renal Carcinoma Metastasis.
Paulo Rodrigues, Saroor A Patel, Louise Harewood, Ioana Olan, Erika Vojtasova, Saiful E Syafruddin, M Nazhif Zaini, Emma K Richardson, Johanna Burge, Anne Y Warren, Grant D Stewart, Kourosh Saeb-Parsy, Shamith A Samarajiwa, Sakari Vanharanta
Jul 25, 2018
Metastases, the spread of cancer cells to distant organs, cause the majority of cancer-related deaths. Few metastasis-specific driver mutations have been identified, suggesting aberrant gene regulation as a source of metastatic...
Identification of sequence changes in myosin II that adjust muscle contraction velocity.
Chloe A Johnson, Jake E McGreig, Sarah T Jeanfavre, Jonathan Walklate, Carlos D Vera, Marta Farré, Daniel P Mulvihill, Anthony J Baines, Martin Ridout, Leslie A Leinwand, Mark N Wass, Michael A Geeves
Jul 21, 2021
The speed of muscle contraction is related to body size; muscles in larger species contract at slower rates. Since contraction speed is a property of the myosin isoform expressed in a muscle, we investigated how sequence changes...
Targeting Methylglyoxal in Diabetic Kidney Disease Using the Mitochondria-Targeted Compound MitoGamide
Sih Min Tan, Runa S. J. Lindblom, Mark Ziemann, Adrienne Laskowski, Cesare Granata, Matthew Snelson, Vicki Thallas-Bonke, Assam El-Osta, Carlos D. Baeza-Garza, Stuart T. Caldwell, Richard C. Hartley, Thomas Krieg, Mark E. Cooper, Michael P. Murphy, Melinda T. Coughlan
Apr 26, 2021
Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive...
Risk Factors for Severe Outcomes in Patients With Systemic Vasculitis and COVID‐19
Matthew A. Rutherford, Jennifer Scott, Maira Karabayas, Marilina Antonelou, Seerapani Gopaluni, David Gray, Joe Barrett, Silke R. Brix, Neeraj Dhaun, Stephen P. McAdoo, Rona M. Smith, Colin C. Geddes, David Jayne, Raashid Luqmani, Alan D. Salama, Mark A. Little, Neil Basu, the UK and Ireland Vasculitis Rare Disease Group (UKIVAS)
Jul 28, 2021
Published by: Arthritis & Rheumatology
Taxonomic signatures of cause-specific mortality risk in human gut microbiome.
Aaro Salosensaari, Ville Laitinen, Aki S Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D Watrous, Tao Long, Rodolfo A Salido, Karenina Sanders, Caitriona Brennan, Gregory C Humphrey, Jon G Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob Knight, Leo Lahti, Teemu Niiranen
Jun 12, 2021
The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally...
The Effects of Acute Δ<sup>9</sup>-Tetrahydrocannabinol on Striatal Glutamatergic Function
Michael A.P. Bloomfield, Katherine Petrilli, Rachel Lees, Chandni Hindocha, Katherine Beck, Ryan J. Turner, Ellis Chika Onwordi, Neil Rane, David J. Lythgoe, James M. Stone, H. Valerie Curran, Oliver D. Howes, Tom P. Freeman
Jun 30, 2021
Background: Cannabis and its main psychoactive component, Δ9-tetrahydrocannabinol (THC), can elicit transient psychotic symptoms. A key candidate biological mechanism of how THC induces psychotic symptoms is the...
Rational Passivation of Sulfur Vacancy Defects in Two-Dimensional Transition Metal Dichalcogenides.
Hope Bretscher, Zhaojun Li, James Xiao, Diana Yuan Qiu, Sivan Refaely-Abramson, Jack A Alexander-Webber, Arelo Tanoh, Ye Fan, Géraud Delport, Cyan A Williams, Samuel D Stranks, Stephan Hofmann, Jeffrey B Neaton, Steven G Louie, Akshay Rao
May 10, 2021
Structural defects vary the optoelectronic properties of monolayer transition metal dichalcogenides, leading to concerted efforts to control defect type and density via materials growth or postgrowth passivation. Here, we...
Taxonomic signatures of cause-specific mortality risk in human gut microbiome
Aaro Salosensaari, Ville Laitinen, Aki S. Havulinna, Guillaume Meric, Susan Cheng, Markus Perola, Liisa Valsta, Georg Alfthan, Michael Inouye, Jeramie D. Watrous, Tao Long, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C. Humphrey, Jon G. Sanders, Mohit Jain, Pekka Jousilahti, Veikko Salomaa, Rob Knight, Leo Lahti, Teemu Niiranen
May 11, 2021
Narrow-band high-lying excitons with negative-mass electrons in monolayer WSe 2
Kai-Qiang Lin, Chin Shen Ong, Sebastian Bange, Paulo E. Faria Junior, Bo Peng, Jonas D. Ziegler, Jonas Zipfel, Christian Bäuml, Nicola Paradiso, Kenji Watanabe, Takashi Taniguchi, Christoph Strunk, Bartomeu Monserrat, Jaroslav Fabian, Alexey Chernikov, Diana Y. Qiu, Steven G. Louie, John M. Lupton
Sep 17, 2021
Abstract: Monolayer transition-metal dichalcogenides (TMDCs) show a wealth of exciton physics. Here, we report the existence of a new excitonic species, the high-lying exciton (HX), in single-layer WSe2 with an energy of ~3.4...
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