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Results: 12021
Catalyst-Mediated Enhancement of Carbon Nanotube Textiles by Laser Irradiation
Thurid S. Gspann, Adarsh Kaniyoor, Wei Tan, Philipp A. Kloza, John S. Bulmer, Jennifer Mizen, Giorgio Divitini, Jeronimo Terrones, Daniel Tune, John D. Cook, Fiona R. Smail, James A. Elliott
Mar 12, 2021
The photonic post-processing of suspended carbon nanotube (CNT) ribbons made by floating catalyst chemical vapor deposition (FC-CVD) results in selective sorting of the carbon nanotubes present. Defective, thermally...
Biomarkers for site-specific response to neoadjuvant chemotherapy in epithelial ovarian cancer
Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.
Michelle Goldsworthy, Nathan L Absalom, David Schröter, Helen C Matthews, Debora Bogani, Lee Moir, Anna Long, Christopher Church, Alison Hugill, Quentin M Anstee, Rob Goldin, Mark Thursz, Florian Hollfelder, Roger D Cox
Jan 22, 2021
We employed a random mutagenesis approach to identify novel monogenic determinants of type 2 diabetes. Here we show that haplo-insufficiency of the histone methyltransferase myeloid-lineage leukemia (Mll2/Wbp7) gene causes type...
Beyond COVID-19
J Bell, G Bianconi, D Butler, J Crowcroft, P C W Davies, C Hicks, H Kim, I Z Kiss, F Di Lauro, C Maple, A Paul, M Prokopenko, P Tee, S Walker
Feb 02, 2021
Abstract: On May 28th and 29th, a two day workshop was held virtually, facilitated by the Beyond Center at ASU and Moogsoft Inc. The aim was to bring together leading scientists with an interest in network science and...
An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes.
Austin D-E Swafford, Joanna MM Howson, Lucy J Davison, Chris Wallace, Deborah J Smyth, Helen Schuilenburg, Meeta Maisuria-Armer, Trupti Mistry, Michael J Lenardo, John A Todd
Feb 08, 2021
OBJECTIVE: IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide association...
A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity
Katharina Koch, Rudolf Hartmann, Julia Tsiampali, Constanze Uhlmann, Ann-Christin Nickel, Xiaoling He, Marcel A. Kamp, Michael Sabel, Roger A. Barker, Hans-Jakob Steiger, Daniel Hänggi, Dieter Willbold, Jaroslaw Maciaczyk, Ulf D. Kahlert
Feb 09, 2021
Abstract: Cancer cells upregulate anabolic processes to maintain high rates of cellular turnover. Limiting the supply of macromolecular precursors by targeting enzymes involved in biosynthesis is a promising strategy in cancer...
Neuroinflammation predicts disease progression in progressive supranuclear palsy
Maura Malpetti, Luca Passamonti, Peter Simon Jones, Duncan Street, Timothy Rittman, Timothy D Fryer, Young T Hong, Patricia Vàsquez Rodriguez, William Richard Bevan-Jones, Franklin I Aigbirhio, John Tiernan O'Brien, James Benedict Rowe
Mar 22, 2021
Introduction: In addition to tau pathology and neuronal loss, neuroinflammation occurs in progressive supranuclear palsy (PSP). However, the prognostic value of the in vivo imaging markers for these processes in PSP remains...
Published by: BMJ Publishing Group
A combination of urinary biomarker panel and PancRISK score for earlier detection of pancreatic cancer
Silvana Debernardi, Harrison O'Brien, Asma S Algahmdi, Nuria Malats, Grant D Stewart, Marija Plješa-Ercegovac, Eithne Costello, William Greenhalf, Amina Saad, Rhiannon Roberts, Alexander Ney, Stephen P Pereira, Hemant M Kocher, Stephen Duffy, Oleg Blyuss, Tatjana Crnogorac-Jurcevic
Nov 23, 2020
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, with around 9% of patients surviving >5 years. Asymptomatic in its initial stages, PDAC is mostly diagnosed late, when already a locally...
Adult Aged Aged 80 and over Antigens Tumor-Associated Carbohydrate Biomarkers Tumor Carcinoma Pancreatic Ductal Early Detection of Cancer Europe Female Humans Lithostathine Male Middle Aged Pancreatic Neoplasms Predictive Value of Tests Reproducibility of Results Retrospective Studies Trefoil Factor-1 Urinalysis Vesicular Transport Proteins Young Adult
The Lantern Vol. 8, No. 2, March 1940
Robert C. Yoh, Harry L. Showalter, Robert J. Weidenhammer, Esther Hydren, Dorothy Kinsey Shisler, Ernest Muller, Helene Berger, Virginia Shoffner, Joseph D. Chapline, Jr., Richard G. Fohl, Evelyn Huber, Gladys Heibel
Jan 01, 0001
The Music of Life The Dice Were Loaded Collecting People Chemistry and Disease Quest Comrade Entity "We Cannot Go On Forever" The Problem Beside a Campfire Smoke Sunset on Winnipesaukee and Varied...
Ursinus College Collegeville Pennsylvania Lantern Literary Magazine poetry fiction Creative Nonfiction Chemistry Medicine Smoke Arts and Humanities Creative Writing fiction illustration Nonfiction poetry
Published by: Ursinus College
The Grizzly, September 30, 1983
Perry Romer, Andrea Butler, Rochelle Stief, Richard P. Richter, Alison K. Brown, Sara D. Seese, Tracey Clark, Kurt Richter, Rosemary J. Wuenschel, Scott Scheffler, Judith Rippert, Timothy Cosgrave, Joseph Klaiber
Jan 01, 0001
Fraternities Speak Out Media Meeting Held Forum Series Begins President's Corner Letters to the Editor Student Profile: Weible on Wheels Guitarist Plays at Ursinus Faculty Lectures Open Everybody's Rockin' Accountants...
Ursinus College Collegeville Pennsylvania newspaper fraternities Student Publications Committee George E. Saurman Zacharias Ursinus Tim Weible Allan Krantz French Club George Fago Neil Young William T. Parsons Pennsylvania Germans Jim O'Brien Volleyball Soccer field hockey cross country Football cultural history Higher Education Liberal Studies Social History United States History
Published by: Ursinus College
Ursinus College Bulletin, February 1975
Robin Clouser, William Schuyler Pettit, John O. Reagle, Mabel Hobson, Ellwood Paisley, Donald L. Helfferich, Calvin D. Yost, John W. DeWire, Roger P. Staiger, Eileen Kinderman, Richard P. Richter
Jan 01, 0001
From the President's desk Memories of Ursinus: Nineteenth century days; Turn-of-the-century emancipated coed; The bell and the tower of the teens; Administrative strain; Drills, shines and dinks; Hooked on physics; Hearse and...
Ursinus College Collegeville Pennsylvania alumni Deaths Marriages James R. Rue reminiscences George W. Hartzell Century II program field hockey Higher Education Social History United States History
Published by: Ursinus College
Social and non-social autism symptoms and trait domains are genetically dissociable
Varun Warrier, Roberto Toro, Hyejung Won, Claire S. Leblond, Freddy Cliquet, Richard Delorme, Ward De Witte, Janita Bralten, Bhismadev Chakrabarti, Anders D. Børglum, Jakob Grove, Geert Poelmans, David A. Hinds, Thomas Bourgeron, Simon Baron-Cohen
Sep 02, 2020
Abstract: The core diagnostic criteria for autism comprise two symptom domains – social and communication difficulties, and unusually repetitive and restricted behaviour, interests and activities. There is some evidence to...
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
Rebecca L. Lloyd, Paul W. G. Wijnhoven, Antonio Ramos-Montoya, Zena Wilson, Giuditta Illuzzi, Katarzyna Falenta, Gemma N. Jones, Neil James, Christophe D. Chabbert, Jonathan Stott, Emma Dean, Alan Lau, Lucy A. Young
Jun 18, 2020
Abstract: The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits PARP1/2 enzymatic activity and traps PARP1 on DNA...
Persistent influence of obliquity on ice age terminations since the Middle Pleistocene transition.
Petra Bajo, Russell N Drysdale, Jon D Woodhead, John C Hellstrom, David Hodell, Patrizia Ferretti, Antje HL Voelker, Giovanni Zanchetta, Teresa Rodrigues, Eric Wolff, Jonathan Tyler, Silvia Frisia, Christoph Spötl, Anthony E Fallick
Apr 01, 2020
Radiometric dating of glacial terminations over the past 640,000 years suggests pacing by Earth's climatic precession, with each glacial-interglacial period spanning four or five cycles of ~20,000 years. However, the lack of...
A solution-processable and ultra-permeable conjugated microporous thermoset for selective hydrogen separation.
Wei Liu, Shu-Dong Jiang, Youguo Yan, Wensen Wang, Jing Li, Kai Leng, Susilo Japip, Jiangtao Liu, Hai Xu, Yanpeng Liu, In-Hyeok Park, Yang Bao, Wei Yu, Michael D Guiver, Sui Zhang, Kian Ping Loh
Jun 01, 2020
The synthesis of a polymer that combines the processability of plastics with the extreme rigidity of cross-linked organic networks is highly attractive for molecular sieving applications. However, cross-linked networks are...
Long-term expansion, genomic stability and in vivo safety of adult human pancreas organoids
Nikitas Georgakopoulos, Nicole Prior, Brigitte Angres, Gianmarco Mastrogiovanni, Alex Cagan, Daisy Harrison, Christopher J. Hindley, Robert Arnes-Benito, Siong-Seng Liau, Abbie Curd, Natasha Ivory, Benjamin D. Simons, Inigo Martincorena, Helmut Wurst, Kourosh Saeb-Parsy, Meritxell Huch
Jun 06, 2020
Abstract: Background: Pancreatic organoid systems have recently been described for the in vitro culture of pancreatic ductal cells from mouse and human. Mouse pancreatic organoids exhibit unlimited expansion potential, while...
External Validation of Risk Prediction Models Incorporating Common Genetic Variants for Incident Colorectal Cancer Using UK Biobank.
Catherine L Saunders, Britt Kilian, Deborah J Thompson, Luke J McGeoch, Simon J Griffin, Antonis C Antoniou, Jon D Emery, Fiona M Walter, Joe Dennis, Xin Yang, Juliet A Usher-Smith
Feb 14, 2020
The aim of this study was to compare and externally validate risk scores developed to predict incident colorectal cancer that include common genetic variants (SNPs), with or without established lifestyle/environmental...
Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture.
N Conte, I Varela, C Grove, N Manes, K Yusa, T Moreno, A Segonds-Pichon, A Bench, E Gudgin, B Herman, N Bolli, P Ellis, D Haddad, P Costeas, R Rad, M Scott, B Huntly, A Bradley, GS Vassiliou
Oct 14, 2020
Advances in sequencing technologies are giving unprecedented insights into the spectrum of somatic mutations underlying acute myeloid leukaemia with a normal karyotype (AML-NK). It is clear that the prognosis of individual...
Preventive digital mental health interventions for children and young people
Aislinn D. Bergin, Elvira Perez Vallejos, E. Bethan Davies, David Daley, Tamsin Ford, Gordon Harold, Sarah Hetrick, Megan Kidner, Yunfei Long, Sally Merry, Richard Morriss, Kapil Sayal, Edmund Sonuga-Barke, Jo Robinson, John Torous, Chris Hollis
Oct 15, 2020
Abstract: Digital health interventions (DHIs) have frequently been highlighted as one way to respond to increasing levels of mental health problems in children and young people. Whilst many are developed to address existing...
Photochromic Fluorescent Probe Strategy for the Super-resolution Imaging of Biologically Important Biomarkers
Xianzhi Chai, Hai Hao Han, Adam C. Sedgwick, Na Li, Yi Zang, Tony D. James, Junji Zhang, Xi Le Hu, Yang Yu, Yao Li, Yan Wang, Jia Li, Xiao Peng He, He Tian
Oct 21, 2020
Here, we report a β-galactosidase (β-Gal)-responsive photochromic fluorescent probe, NpG, that was designed to prebind to human serum albumin (HSA) to form the probe/protein hybrid, NpG@HSA. The formation of NpG@HSA led to an...
Fermi surfaces and orbital polarization in superconducting CeO0.5 F0.5BiS2 revealed by angle-resolved photoemission spectroscopy
T Sugimoto, D Ootsuki, C Morice, E Artacho, SS Saxena, EF Schwier, M Zheng, Y Kojima, H Iwasawa, K Shimada, M Arita, H Namatame, M Taniguchi, M Takahashi, NL Saini, T Asano, R Higashinaka, TD Matsuda, Y Aoki, T Mizokawa
Aug 10, 2017
We have investigated the electronic structure of BiS2-based CeO0.5F0.5BiS2 superconductor using polarization-dependent angle-resolved photoemission spectroscopy (ARPES), and succeeded in elucidating the orbital characters on the...
Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS
AJ Narvaez, S Ber, A Crooks, A Emery, B Hardwick, E Guarino Almeida, DJ Huggins, D Perera, M Roberts-Thomson, R Azzarelli, FE Hood, IA Prior, DW Walker, R Boyce, RG Boyle, SP Barker, CJ Torrance, GJ McKenzie, AR Venkitaraman
Sep 25, 2017
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