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Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent
Victor Laserna, Daniel Abegg, Cláudia F. Afonso, Esther M. Martin, Alexander Adibekian, Peter Ravn, Francisco Corzana, Gonçalo J. L. Bernardes
Sep 29, 2021
Abstract: We describe maleic‐acid derivatives as robust cysteine‐selective reagents for protein labelling with comparable kinetics and superior stability relative to maleimides. Diamide and amido‐ester derivatives proved to be...
RESEARCH ARTICLE RESEARCH ARTICLES bioconjugation Cysteine Irreversibility Maleimides Michael addition
Published by: Angewandte Chemie International Edition
Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation
George S. Biggs, Oskar James Klein, Sarah L. Maslen, J. Mark Skehel, Trevor J. Rutherford, Stefan M. V. Freund, Florian Hollfelder, Sally R. Boss, Paul D. Barker
Apr 26, 2021
RESEARCH ARTICLE RESEARCH ARTICLES direct coordination Ligand exchange metalloenzymes Ruthenium transfer hydrogenation
Published by: Angewandte Chemie International Edition
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
Juraj Konč, Libby Brown, Daniel R. Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo J. L. Bernardes
Nov 03, 2021
Abstract: Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site‐specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for...
RESEARCH ARTICLE RESEARCH ARTICLES Antibodies bioconjugation Imaging Mass Spectrometry Nucleic Acids
Published by: Angewandte Chemie International Edition
Biopolymer‐based Carriers for DNA Vaccine Design
Christoph O. Franck, Luise Fanslau, Andrea Bistrovic Popov, Puneet Tyagi, Ljiljana Fruk
Jun 04, 2021
Abstract: Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers....
Published by: Angewandte Chemie International Edition