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Results: 8
Spectrum, risk factors and outcomes of neurological and psychiatric complications of COVID-19
Amy L Ross Russell, Marc Hardwick, Athavan Jeyanantham, Laura M White, Saumitro Deb, Girvan Burnside, Harriet M Joy, Craig J Smith, Thomas A Pollak, Timothy R Nicholson, Nicholas W S Davies, Hadi Manji, Ava Easton, Stephen Ray, Michael S Zandi, Jonathan P Coles, David K Menon, Aravinthan Varatharaj, Beth McCausland, Mark A Ellul, Naomi Thomas, Gerome Breen, Stephen Keddie, Michael P Lunn, John P S Burn, Graziella Quattrocchi, Luke Dixon, Claire M Rice, George Pengas, Rustam Al-Shahi Salman, Alan Carson, Eileen M Joyce, Martin R Turner, Laura A Benjamin, Tom Solomon, Rachel Kneen, Sarah Pett, Rhys H Thomas, Benedict D Michael, Ian Galea
Sep 19, 2021
SARS-CoV-2 is associated with new-onset neurological and psychiatric conditions. Detailed clinical data, including factors associated with recovery, are lacking, hampering prediction modelling and targeted therapeutic...
Published by: Brain communications
High-throughput imaging of ATG9A distribution as a diagnostic functional assay for adaptor protein complex 4-associated hereditary spastic paraplegia
D Ebrahimi-Fakhari, JE Alecu, B Brechmann, M Ziegler, K Eberhardt, H Jumo, A D'Amore, P Habibzadeh, MA Faghihi, JL De Bleecker, S Vuillaumier-Barrot, S Auvin, FM Santorelli, S Neuser, B Popp, E Yang, L Barrett, AK Davies, A Saffari, J Hirst, M Sahin
Jan 06, 2022
Adaptor protein complex 4-associated hereditary spastic paraplegia is caused by biallelic loss-of-function variants in AP4B1, AP4M1, AP4E1 or AP4S1, which constitute the four subunits of this obligate...
hereditary spastic paraplegia Adaptor Protein Complex 4 functional assay High-throughput imaging biomarker
Published by: Brain communications
[<sup>18</sup>F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.
Elijah Mak, Antonina Kouli, Negin Holland, Nicolas Nicastro, George Savulich, Ajenthan Surendranathan, Maura Malpetti, Roido Manavaki, Young T Hong, Tim D Fryer, Franklin Aigbirhio, James B Rowe, John T O'Brien, Caroline H Williams-Gray
Oct 07, 2021
Published by: Brain communications
Pathogenic <i>NR2F1</i> variants cause a developmental ocular phenotype recapitulated in a mutant mouse model.
Neringa Jurkute, Michele Bertacchi, Gavin Arno, Chiara Tocco, Ungsoo Samuel Kim, Adam M Kruszewski, Robert A Avery, Emma C Bedoukian, Jinu Han, Sung Jun Ahn, Nikolas Pontikos, James Acheson, Indran Davagnanam, Richard Bowman, Marios Kaliakatsos, Alice Gardham, Emma Wakeling, Ngozi Oluonye, Maddy Ashwin Reddy, Elaine Clark, Elisabeth Rosser, Patrizia Amati-Bonneau, Majida Charif, Guy Lenaers, Isabelle Meunier, Sabine Defoort, Catherine Vincent-Delorme, Anthony G Robson, Graham E Holder, Luc Jeanjean, Antonio Martinez-Monseny, Mariona Vidal-Santacana, Chloé Dominici, Cedric Gaggioli, Nadia Giordano, Matteo Caleo, Grant T Liu, Andrew R Webster, Michèle Studer, Patrick Yu-Wai-Man
Oct 02, 2021
Published by: Brain communications
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer's disease.
Dimitrios I Sideris, John S H Danial, Derya Emin, Francesco S Ruggeri, Zengjie Xia, Yu P Zhang, Evgeniia Lobanova, Helen Dakin, Suman De, Alyssa Miller, Jason C Sang, Tuomas P J Knowles, Michele Vendruscolo, Graham Fraser, Damian Crowther, David Klenerman
Sep 16, 2021
Protein aggregation likely plays a key role in the initiation and spreading of Alzheimer's disease pathology through the brain. Soluble aggregates of amyloid beta are believed to play a key role in this process. However, the...
Published by: Brain communications