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Blood brain barrier (BBB) conserves unique regulatory system to maintain barrier tightness while allowing adequate transport between neurovascular units. This mechanism possess a challenge for drug delivery, while abnormality...

blood brain barrier Cytokines Developmental mechanical stress miRNA Tight Junctions physicochemical transcytosis

The peak width of skeletonized mean diffusivity (PSMD) has been proposed as a fully automated imaging marker of relevance to cerebral small vessel disease (SVD). We assessed PSMD in relation to conventional SVD markers, global...

The physical continuity of axons over long cellular distances poses challenges for their maintenance. One organelle that faces this challenge is endoplasmic reticulum (ER); unlike other intracellular organelles, this forms a...

Endoplasmic Reticulum neurodegeneration calcium stores Axonal Transport hereditary spastic paraplegia organelle contact sites smooth ER

Maternal immune activation (MIA) is mediated by activation of inflammatory pathways resulting in increased levels of cytokines and chemokines that cross the placental and blood-brain barriers altering fetal neural development....

Schizophrenia LPS autism Poly(I:C) Autism spectrum conditions maternal immune activation (MIA) SARS-CoV-2

Transcranial magnetic stimulation (TMS) holds potential promise as a therapeutic modality for disorders of addiction. Our previous findings indicate that high-frequency repetitive transcranial magnetic stimulation (rTMS) over...

α-Synuclein (αS) is a presynaptic protein whose aggregation is associated with Parkinson's disease (PD). Although the physiological function of αS is still unclear, several lines of evidence indicate that this protein may play a...

Cholesterol Nuclear Magnetic Resonance membrane interaction α-synuclein Synaptic Vesicles