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Results: 6
We need to think about data governance for dementia research in a digital era.
BACKGROUND:Research into Alzheimer's disease and other dementias increasingly involves large-scale data-sharing initiatives. The development of novel digital tools and assessments is likely to increase the need for these. This...
Published by: Alzheimer's research & therapy
Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort
Lisa Vermunt, Graciela Muniz-Terrera, Lea ter Meulen, Colin Veal, Kaj Blennow, Archie Campbell, Isabelle Carrié, Julien Delrieu, Karine Fauria, Gema Huesa Rodríguez, Silvia Ingala, Natalie Jenkins, José Luis Molinuevo, Pierre-Jean Ousset, David Porteous, Niels D Prins, Alina Solomon, Brian D Tom, Henrik Zetterberg, Marissa Zwan, Craig W Ritchie, Philip Scheltens, Gerald Luscan, Anthony J Brookes, Pieter Jelle Visser
Feb 07, 2020
BACKGROUND:Recruitment is often a bottleneck in secondary prevention trials in Alzheimer disease (AD). Furthermore, screen-failure rates in these trials are typically high due to relatively low prevalence of AD pathology in...
Amyloid Recruitment engagement Registries Secondary prevention trials Prescreening Trial-ready cohort
Published by: Alzheimer's research & therapy
EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer's disease.
Julia Schumacher, Alan J Thomas, Luis R Peraza, Michael Firbank, Ruth Cromarty, Calum A Hamilton, Paul C Donaghy, John T O'Brien, John-Paul Taylor
May 24, 2020
BACKGROUND:Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is characterised by marked deficits within the cholinergic system which are more severe than in...
Nucleus basalis of Meynert Structural MRI dementia with Lewy bodies Resting state EEG Parkinson’s disease dementia
Published by: Alzheimer's research & therapy
The Revised Self-Monitoring Scale detects early impairment of social cognition in genetic frontotemporal dementia within the GENFI cohort.
Hannah D Franklin, Lucy L Russell, Georgia Peakman, Caroline V Greaves, Martina Bocchetta, Jennifer Nicholas, Jackie Poos, Rhian S Convery, David M Cash, John van Swieten, Lize Jiskoot, Fermin Moreno, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B Rowe, Elizabeth Finger, Matthis Synofzik, Rik Vandenberghe, Alexandre de Mendonça, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Jonathan D Rohrer
Aug 13, 2021
Background
Although social cognitive dysfunction is a major feature of frontotemporal dementia (FTD), it has been poorly studied in familial forms. A key goal of studies is to detect early cognitive impairment using...
Published by: Alzheimer's research & therapy
Societal and equity challenges for Brain Health Services. A user manual for Brain Health Services-part 6 of 6.
Richard Milne, Daniele Altomare, Federica Ribaldi, José Luis Molinuevo, Giovanni B Frisoni, Carol Brayne
Nov 22, 2021
Brain Health Services are a novel approach to the personalized prevention of dementia. In this paper, we consider how such services can best reflect their social, cultural, and economic context and, in doing so, deliver fair and...
Published by: Alzheimer's research & therapy
Modifiable risk factors for dementia and dementia risk profiling. A user manual for Brain Health Services-part 2 of 6.
Janice M Ranson, Timothy Rittman, Shabina Hayat, Carol Brayne, Frank Jessen, Kaj Blennow, Cornelia van Duijn, Frederik Barkhof, Eugene Tang, Catherine J Mummery, Blossom C M Stephan, Daniele Altomare, Giovanni B Frisoni, Federica Ribaldi, José Luis Molinuevo, Philip Scheltens, David J Llewellyn
Nov 22, 2021
We envisage the development of new Brain Health Services to achieve primary and secondary dementia prevention. These services will complement existing memory clinics by targeting cognitively unimpaired individuals, where the...
aging Prevention Alzheimer’s disease Dementia Risk Factors Public Health Risk profiling Brain Health Services
Published by: Alzheimer's research & therapy