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The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation <i>In Vitro</i>.
Christopher M Gaunt, Daniel B Rainbow, Ruairi J Mackenzie, Lorna B Jarvis, Hani S Mousa, Nicholas Cunniffe, Zoya Georgieva, J William Brown, Alasdair J Coles, Joanne L Jones
Sep 27, 2021
Published by: Frontiers in immunology
The Diverse Major Histocompatibility Complex Haplotypes of a Common Commercial Chicken Line and Their Effect on Marek's Disease Virus Pathogenesis and Tumorigenesis.
Luca D Bertzbach, Clive A Tregaskes, Rebecca J Martin, Undine-Sophie Deumer, Lan Huynh, Ahmed M Kheimar, Andelé M Conradie, Jakob Trimpert, Jim Kaufman, Benedikt B Kaufer
Jul 14, 2022
The major histocompatibility complex (MHC) is crucial for appropriate immune responses against invading pathogens. Chickens possess a single predominantly-expressed class I molecule with strong associations between disease...
resistance SUSCEPTIBILITY B19 B9 major histocompatibility complex (MHC) B15 B21 Valo Animals Chickens Herpesvirus 2 Gallid Marek Disease Histocompatibility Antigens Major Histocompatibility Complex Haplotypes Disease Resistance Carcinogenesis
Published by: Frontiers in immunology
Leupaxin Expression Is Dispensable for B Cell Immune Responses.
Amélie Bonaud, Simon Clare, Valeria Bisio, John M Sowerby, Shugang Yao, Hanne Ostergaard, Karl Balabanian, Kenneth G C Smith, Marion Espéli
May 10, 2020
The generation of a potent humoral immune response by B cells relies on the integration of signals induced by the B cell receptor, toll-like receptors and both negative and positive co-receptors. Several reports also suggest...
Published by: Frontiers in immunology
PI3K in T Cell Adhesion and Trafficking.
Kristoffer H Johansen, Dominic P Golec, Julie H Thomsen, Pamela L Schwartzberg, Klaus Okkenhaug
Sep 23, 2021
PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant mouse models and PI3K inhibitors....
Published by: Frontiers in immunology
Lactate exposure shapes the metabolic and transcriptomic profile of CD8+ T cells.
Laura Barbieri, Pedro Veliça, Paulo A Gameiro, Pedro P Cunha, Iosifina P Foskolou, Eric Rullman, David Bargiela, Randall S Johnson, Helene Rundqvist
Apr 15, 2023
metabolism Oxygen lactate Transcriptome CD8+ T cells CD8-Positive T-Lymphocytes T-Lymphocytes Cytotoxic Animals Humans Mice Lactic Acid Sodium Lactate
Published by: Frontiers in immunology
Development of Lentiviral Vectors Pseudotyped With Influenza B Hemagglutinins
Francesca Ferrara, Joanne Marie M Del Rosario, Kelly A S da Costa, Rebecca Kinsley, Simon Scott, Sasan Fereidouni, Craig Thompson, Paul Kellam, Sarah Gilbert, George Carnell, Nigel Temperton
Jul 28, 2021
Influenza B viruses (IBV) cause respiratory disease epidemics in humans and are therefore components of seasonal influenza vaccines. Serological methods are employed to evaluate vaccine immunogenicity prior to licensure....
Influenza B serosurveillance lentiviral (LV) vector pseudotype viral particles pseudotype neutralization
Published by: Frontiers in immunology
KIR Variation in Iranians Combines High Haplotype and Allotype Diversity With an Abundance of Functional Inhibitory Receptors.
Claudia Alicata, Elham Ashouri, Neda Nemat-Gorgani, Lisbeth A Guethlein, Wesley M Marin, Sudan Tao, Lorenzo Moretta, Jill A Hollenbach, John Trowsdale, James A Traherne, Abbas Ghaderi, Peter Parham, Paul J Norman
May 18, 2020
Natural killer (NK) cells are innate lymphocytes that eliminate infected and transformed cells. They discriminate healthy from diseased tissue through killer cell Ig-like receptor (KIR) recognition of HLA class I ligands....
Published by: Frontiers in immunology
Glycan masking of a non-neutralising epitope enhances neutralising antibodies targeting the RBD of SARS-CoV-2 and its variants.
George W Carnell, Martina Billmeier, Sneha Vishwanath, Maria Suau Sans, Hannah Wein, Charlotte L George, Patrick Neckermann, Joanne Marie M Del Rosario, Alexander T Sampson, Sebastian Einhauser, Ernest T Aguinam, Matteo Ferrari, Paul Tonks, Angalee Nadesalingam, Anja Schütz, Chloe Qingzhou Huang, David A Wells, Minna Paloniemi, Ingo Jordan, Diego Cantoni, David Peterhoff, Benedikt Asbach, Volker Sandig, Nigel Temperton, Rebecca Kinsley, Ralf Wagner, Jonathan L Heeney
Apr 12, 2023
The accelerated development of the first generation COVID-19 vaccines has saved millions of lives, and potentially more from the long-term sequelae of SARS-CoV-2 infection. The most successful vaccine candidates have used the...
neutralising antibodies receptor binding domain (RBD) SARS-CoV-2 antibody pseudotype neutralisation glycan masking Humans Polysaccharides Epitopes Antibodies Neutralizing covid-19 SARS-CoV-2 COVID-19 Vaccines
Published by: Frontiers in immunology